αEffect of high dose of astragalus membranaceus on serum TNF- ,IL-6 and cellular immune function in patients with chronic glomerulonephritis

您当前的位置：

首页 >

文章列表页 >

αEffect of high dose of astragalus membranaceus on serum TNF- ,IL-6 and cellular immune function in patients with chronic glomerulonephritis

更新时间：2024-01-17

- αEffect of high dose of astragalus membranaceus on serum TNF- ,IL-6 and cellular immune function in patients with chronic glomerulonephritis
- Journal of Chongqing Medical University Issue 2, Pages: 174-176(2002)
- 作者机构：
  
  1. 重庆医科大学第二临床学院神经内科
  2. 重庆医科大学临床学院中西医结合科
  4. ,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R277.592.3
- Published：2002，
扫描看全文
[1]陈莉芬,李荣亨,曹文富,张晓恒,高渝军.黄芪对慢性肾炎患者血清TNF-α、IL-6及细胞免疫功能的影响[J].重庆医科大学学报,2002(02):174-176.

αEffect of high dose of astragalus membranaceus on serum TNF- ,IL-6 and cellular immune function in patients with chronic glomerulonephritis. [J]. Journal of Chongqing Medical University (2):174-176(2002)
[1]陈莉芬,李荣亨,曹文富,张晓恒,高渝军.黄芪对慢性肾炎患者血清TNF-α、IL-6及细胞免疫功能的影响[J].重庆医科大学学报,2002(02):174-176. DOI：

αEffect of high dose of astragalus membranaceus on serum TNF- ,IL-6 and cellular immune function in patients with chronic glomerulonephritis. [J]. Journal of Chongqing Medical University (2):174-176(2002) DOI：

摘要

目的:观察大剂量黄芪对慢性肾小球肾炎（CGN）患者血清肿瘤坏死因子α-（TNF-）α、白介素（IL-6）及细胞-6免疫功能的影响。方法:采用放射免疫法测定例患者（治疗组）应用大剂量黄芪注射液治疗前后血清α、水40CGNTNF-IL-6平;并与例应用常规治疗的患者（对照组）及名健康人（健康对照组）进行比较

同时观察细胞免疫功能的变化。32 31结果:治疗前两组患者较健康对照组α和均显著升高（TNF-IL-6P）

且血α与之间呈显著正相关（<0.01TNF-IL-6 P）。<0.01治疗后治疗组血α、明显下降TNF-IL-6 （P

<0.01）CD3+细胞、TCD4+细胞、明显升高。TCD4/CD8结论:大剂量黄芪有较好的降低患者α和、改善其细胞免疫功能的作用

为该药治疗提供了理论依据。CGNTNF-IL-6CGN

Abstract

Objective: To observe the effect of high doses of astragalus membranaceus on serum tumor necrosis factor-αα(TNF-)

Interleukin-6(IL-6) and cellular immune function in patients with chronic glomerulonephritis (CGN). Methodsα: Radioimmunoassay (RIA) was used to examine the levels of TNF- and IL-6 in serum before and after treatment with astragalus membranaceus in 30 patients (treated group)

compared with that of 30 patients before and after treatment with routine therapy (control group) and 30 healthy subjects (healthy group) . Changes of CD3+ cells

CD4+ cells

CD8+ cells and CD4+/CD8+ were also observed. Resultsα: Before treatment

serum TNF- and IL-6 were significantly higher (P<0.01) in the treated and the control group compared with those in the healthy αgroup. There was significant positive correlation between serum TNF-and serum IL-6. After treatment

the αimprovement of TNF-

IL-6

CD3+ cells

CD4+ cells

CD4+/CD8+ in the treated group were obvious (P<0.01)

and the improvement in the treated group was more significant than that of control group (P<0.05

P<0.01). Conclusion: αHigh doses of astragalus membranaceus can decrease the levels of serum TNF- and IL-6 and improve cellular immune function in CGN patients. The research suggests its possible curative mechanism.

关键词

黄芪慢性肾小球肾炎肿瘤坏死因子-α白介素-6细胞免疫功能

Keywords

astragalus membranaceusChronic glomerulonephritistumor necrosis factor-αinterleukin-6Cellular immune function

references

Views

217

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of Chemerin on ovarian granulosa cells and pathogenesis of polycystic ovary syndrome

Correlation between serum Hcy and cytokines in patients with elderly hypertension

Correlation between the levels of serum HMGB1 and TNF-α and cardiac function in patients with diabetic kidney disease

Effect of extracorporeal shock wave with Chuan-zhi Plaster on expression of interleukin-1β and tumor necrosisfactor-α in cartilage in rabbits with knee osteoarthritis

Effect of Yuxing Dilong decoction on smoking cession and chronic obstructive pulmonary diseases

Related Author

Luo Xiaodong

Gan Xiaolin

Gong Yangyang

Hu Jianguo

Cai Liuyun

Liu Yong

Zhang Ziqu

Liu Shuqin

Related Institution

Department of Obstetrics and Gynecology，Second Affiliated Hospital of Chongqing Medical University

Department of Cardiology，The Third People’s Hospital of Zigong City

Department of Cardiology，Affiliated Hospital of Chengdu University of Traditional Chinese Medicine

Department of Nephrology, The Affiliated Huai'an No.1 People’s Hospital of Nanjing Medical University

Department of Endocrinology, The Affiliated Huai'an No.1 People’s Hospital of Nanjing Medical University

⁰