Vascular and endothelial function in hypercholesterolemic rats

QIN Jianet al

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Vascular and endothelial function in hypercholesterolemic rats

更新时间：2024-01-17

- Vascular and endothelial function in hypercholesterolemic rats
- Journal of Chongqing Medical University Issue 2, Pages: 127-129(2002)
- 作者机构：
  
  1. 重庆医科大学临床学院心血管内科
  2. 重庆医科大学基础医学院药理教研室
  3. 重庆医科大学临床学院内分泌科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R589.2
- Published：2002，
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[1]秦俭,陈运贞,周歧新,蒋青松,倪银星.高脂血症大鼠的血管和内皮功能[J].重庆医科大学学报,2002(02):127-129.

QIN Jianet al. Vascular and endothelial function in hypercholesterolemic rats. [J]. Journal of Chongqing Medical University (2):127-129(2002)
[1]秦俭,陈运贞,周歧新,蒋青松,倪银星.高脂血症大鼠的血管和内皮功能[J].重庆医科大学学报,2002(02):127-129. DOI：

QIN Jianet al. Vascular and endothelial function in hypercholesterolemic rats. [J]. Journal of Chongqing Medical University (2):127-129(2002) DOI：

摘要

目的:研究高脂血症大鼠的血管、内皮功能。方法:只雄性大鼠随机分为正常组和高胆固醇高脂饮食16Wistar 组

喂养周

测定血清一氧化氮（）和血浆内皮素（）水平

离体做主动脉条片对新福林的收缩反应、对乙酰胆12NOET（PE）碱（）和硝普钠（）的舒张反应。AchSNP结果:两组大鼠和水平无显著性差异;主动脉条片对的收缩反应、对NOETPEAch和的舒张反应亦无显著性差异。SNP结论:高脂血症大鼠的血管、内皮功能均未发生明显改变。

Abstract

Objective: To study the effect of hypercholesterolemia on vascular and endothelial function in Wistar rats. Methods: Male Wistar rats were fed 2 % cholesterol diet for 12 weeks. Blood was drawn to determine the level of serum nitric oxide (NO) and plasma endothelin (ET); thoracic aorta was harvested for studies of vascular reactivity to phenylephrine (PE)

acetylcholine (Ach) and sodium nitroprusside (SNP). Results: There were no significant differences between NC and HC group in the level of serum NO and plasma ET ( P<0.05); responses (including the maximal responses) of the thoracic aorta to PE

Ach and SNP were not affected by 2% cholesterol diet. Conclusion: Vascular systolic function and diastolic function were not altered in hypercholesterole-mic rats.

关键词

高脂血症血管功能内皮功能Wistar大鼠

Keywords

HypercholesterolemiaVascular functionEndothelial functionWistar rats

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