The observation of CD44 on differentiation and vascular invasion in hepatocellular carcinoma

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The observation of CD44 on differentiation and vascular invasion in hepatocellular carcinoma

更新时间：2024-01-17

- The observation of CD44 on differentiation and vascular invasion in hepatocellular carcinoma
- Journal of Chongqing Medical University Issue 3, Pages: 247-249(2002)
- 作者机构：
  
  1. 重庆医科大学病理教研室
  2. 重庆医科大学病理教研,重庆,400016
  3. 室重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R735.7
- Published：2002，
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[1]管小琴,徐曼,李圆圆,王朝杰.CD44与肝细胞癌的分化和血管浸润[J].重庆医科大学学报,2002(03):247-249.

The observation of CD44 on differentiation and vascular invasion in hepatocellular carcinoma. [J]. Journal of Chongqing Medical University (3):247-249(2002)
[1]管小琴,徐曼,李圆圆,王朝杰.CD44与肝细胞癌的分化和血管浸润[J].重庆医科大学学报,2002(03):247-249. DOI：

The observation of CD44 on differentiation and vascular invasion in hepatocellular carcinoma. [J]. Journal of Chongqing Medical University (3):247-249(2002) DOI：

摘要

目的:了解在肝细胞癌的表达及其与瘤组织的分化和血管浸润的关系。CD44方法:用免疫组化方法对例人体肝67癌组织做和检测

其中例伴肝内血管浸润

例伴癌旁非癌肝组织。CD44sCD44v61547结果:例肝癌组织阳性14CD44s（

）

与癌旁肝组织（

）无显著差异（14/6720.90%5/4710.64%P>）。例肝癌组织阳性（

0.0518CD44v618/67）

与癌旁肝组织（）有明显差异（26.87%0/47P<）。二者表达均与肿瘤分化和血管浸润无关（0.01P>）。0.05结论:肝细胞癌的高表达较有意义。两者与肿瘤的分化和肝内血管浸润无关。CD44v6CD44s

Abstract

Objective: The purpose of the experiment is to examine the expressions of CD44 on hepatocellular carcinomas and to study the effects on the differentiation and vascular invasion. Methods: Sixty-seven specimens of hepatocellular carcinoma were obtained from surgical excisions (15 cases with intrahepatic vascular invasions and 47 with both cancerous and non-cancerous liver tissue). Immunohistochemical stainings of CD44s and CD44v6 were performed

and SPSS software was applied for statistical analysis. Results: Fourteen cases were (

)(

)CD44s positive in the tumor tissues14/6720.90%and CD44v6 positive in 18 cases 18/6726.87%. (Both expressions correlated with neither tumor cell differentiation nor vascular invasionP>)0.05. Compared (with the non-cancerous liver tissue

CD44v6 was significantly differentP<)0.01. Conclusion: The overexpression of CD44v6 in hepatocellular carcinoma is more significant than that of CD44s. However

they were not correlated with differentiation and intrahepatic vascular invasion.

关键词

CD44肝细胞癌分化血管

Keywords

CD44hepatocellular carcinomadifferentiationVasculum

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