Significance of TGF-β<sub>2</sub> expression in the retina of diabetic hamster

PENG Hui; et al

您当前的位置：

首页 >

文章列表页 >

Significance of TGF-β₂ expression in the retina of diabetic hamster

更新时间：2024-01-17

- Significance of TGF-β₂ expression in the retina of diabetic hamster
- Journal of Chongqing Medical University Issue 6, Pages: 827-830(2006)
- 作者机构：
  
  1. 重庆医科大学附属第一医院眼科
  2. 重庆医科大学附属第一医院耳鼻喉科
  3. 重庆医科大学组织胚胎学教研室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R774.1
- Published：2006，
扫描看全文
[1]彭惠,洪苏玲,陶永贤,姜蓉.转化生长因子-β_2在糖尿病仓鼠视网膜中的表达意义[J].重庆医科大学学报,2006(06):827-830.

PENG Hui, et al. Significance of TGF-β₂ expression in the retina of diabetic hamster. [J]. Journal of Chongqing Medical University (6):827-830(2006)
[1]彭惠,洪苏玲,陶永贤,姜蓉.转化生长因子-β_2在糖尿病仓鼠视网膜中的表达意义[J].重庆医科大学学报,2006(06):827-830. DOI：

PENG Hui, et al. Significance of TGF-β₂ expression in the retina of diabetic hamster. [J]. Journal of Chongqing Medical University (6):827-830(2006) DOI：

摘要

目的:探讨糖尿病视网膜损伤和转化生长因子-β（2TGFβ2）产生的关系以及TGF-β2的作用机制。方法:链脲佐菌素制备仓鼠糖尿病模型

用免疫组织化学法检测正常对照组和糖尿病动物模型（16周）视网膜中TGF-β2的表达

电镜观察其超微结构的变化。结果:糖尿病仓鼠视网膜内TGF-β2表达呈阳性染色反应

超微结构出现膜盘结构分层

数量稀少;节细胞层内质网扩张

核周间隙扩大

细胞内线粒体肿胀等变化。结论:提示TGF-β2与糖尿病视网膜病变（DR）形成过程有关。

Abstract

Objective:To investigate the relations between diabetic retinal damage and the generation of transforming growth factorβ2(TGF-β2)and the function mechanism of TGF-β2.Methods:The diabetic hamster model was established by injection of streptozotocin.The expression of TGF-β2 in the retina of the diabetic hamsters(16w) was determined by immunohistochemicaI technique

Changes of ultrastructure were observed by electron microscope.Results:The reaction for TGF-β2 was negative in normal retina.However

TGF-β2 did express in the retina of diabetic hamsters.Ultrastructure made evident changes.Conclusion:TGF-β2 plays a significant role in the development of diabetic retinopathy.

关键词

糖尿病视网膜病变转化生长因子-β2糖尿病仓鼠动物模型免疫组织化学法

Keywords

diabetic retinopathyTransforming growth factorβ2Diabetes hamster animal modelImmunohistochemical staining

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effects of high glucose concentration on MMP-2 expression and cell cycle in cultured human umbilical vein endothelial cells

The retinal hemodynamic changes after panretinal photocoagulation for the patients with early diabetic retinopathy

Efficacy of pars plana vitrectomy assisted by bevacizumab in the treatment of proliferative diabetic retinopathy：a systematic review

Risk factors of secondary neovascular glaucoma after vitrectomy for proliperative diabetic retinopathy

Significance of serum 25-hydroxyvitam in D3 level in familial type 2 diabetes mellitus with diabetic retinopathy in Kunming

Related Author

张黎

周希

李静

李平华

et al

PENG Hui

易笃友

et al

Related Institution

重庆医科大学附属第一医院眼科

Department of Opthalmology,the Affiliated Hospital of Yongzhou Vocational and Technical College in Hunan Province

永州职业技术学院附属医院准分子治疗中心

Department of Ophthalmolog，The First Affiliated Hospital of Chongqing Medical University，Chongqing Key Laboratory of Ophthalmology

Department of Ophthalmology，The First Affiliated Hospital of Chongqing Medical University

⁰

Significance of TGF-β2 expression in the retina of diabetic hamster

DOI：

摘要

Abstract

关键词

Keywords

references

Significance of TGF-β₂ expression in the retina of diabetic hamster