Effect of HSP90 inhibins geldanamycin on invasion and metastasis of human breast cancer cell line

LUO Hongxia; et al

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Effect of HSP90 inhibins geldanamycin on invasion and metastasis of human breast cancer cell line

更新时间：2024-01-17

- Effect of HSP90 inhibins geldanamycin on invasion and metastasis of human breast cancer cell line
- Journal of Chongqing Medical University Issue 1, Pages: 55-57(2006)
- 作者机构：
  
  1. 重庆医科大学基础医学院病理生理教研室
  2. 重庆医科大学基础医学院病理生理教研室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.9
- Published：2006，
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[1]罗红霞,邓华瑜,郑维萍.HSP90的抑制剂Geldanamycin对乳腺癌细胞侵袭、转移能力的影响[J].重庆医科大学学报,2006(01):55-57+73.

LUO Hongxia, et al. Effect of HSP90 inhibins geldanamycin on invasion and metastasis of human breast cancer cell line. [J]. Journal of Chongqing Medical University (1):55-57(2006)
[1]罗红霞,邓华瑜,郑维萍.HSP90的抑制剂Geldanamycin对乳腺癌细胞侵袭、转移能力的影响[J].重庆医科大学学报,2006(01):55-57+73. DOI：

LUO Hongxia, et al. Effect of HSP90 inhibins geldanamycin on invasion and metastasis of human breast cancer cell line. [J]. Journal of Chongqing Medical University (1):55-57(2006) DOI：

摘要

目的:探讨H SP90抑制剂Geldanam ycin（GA）对高转移性乳腺癌细胞株M DA-MB-231、MDA-M B-435s侵袭、转移能力的影响。方法:噻唑兰比色（M TT）法检测两株细胞对人工基底膜（Matrigel）的粘附能力变化;TranswellCham ber体外侵袭运动实验研究GA处理前后M DA-M B-231、M DA-M B-435s细胞侵袭、运动能力的改变。结果:GA处理后的M DA-M B-231和M DA-MB-435s细胞的粘附、侵袭、运动能力与未处理组细胞相比均明显下降

差异具有显著性（P<0.05和P<0.01）。结论:H SP90抑制剂Geldanam ycin（GA）能够明显抑制乳腺癌细胞株M DA-MB-231、MDA-M B-435s粘附、侵袭和运动能力。

Abstract

Objective:To investigate the effects of HSP90 inhibitors Geldanamycin(GA) on invasion and motility potential in human breast cancer cell.Methods: The effects of HSP90 inhibitor GA on the adhesion?invasion and metastasis of human breast cancer line MDA-MB-231 and MDA-MB-435s in vitro were explored by MTT colorimetric and transwell chamber.Results: Treatd with GA

the adhesion? invasion and motility abilities of the MDA-MB-231 and MDA-MB-435s cells were decreased significantly as compared with the control guoup

(P<0.05 and P<0.01).Conclusion: The abilities of adhesion?invasion and motility of breast cancer cells can be suppressed by the inhibition of GA.

关键词

乳腺癌细胞GeldanamycinHSP90

Keywords

breast cancer cellGeldanamycinHSP90

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