An tentative radiological and basical studies of preventing the constriction after the laminectomy by using the nano-hydroxyapatite/polyamide-66 composite material artificial vertebral lamina

XIAO Zhibo; et al

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An tentative radiological and basical studies of preventing the constriction after the laminectomy by using the nano-hydroxyapatite/polyamide-66 composite material artificial vertebral lamina

更新时间：2024-01-17

- An tentative radiological and basical studies of preventing the constriction after the laminectomy by using the nano-hydroxyapatite/polyamide-66 composite material artificial vertebral lamina
- Journal of Chongqing Medical University Issue 4, Pages: 489-493(2006)
- 作者机构：
  
  1. 重庆医科大学附属第一医院放射科
  2. 重庆医科大学附属第一医院骨科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R445;R687
- Published：2006，
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[1]肖智博,吕富荣,吕发金,蒋电明,唐文胜.纳米羟基磷灰石/聚酰胺复合材料预防椎板切除后椎管狭窄、粘连的初步影像研究[J].重庆医科大学学报,2006(04):489-493.

XIAO Zhibo, et al. An tentative radiological and basical studies of preventing the constriction after the laminectomy by using the nano-hydroxyapatite/polyamide-66 composite material artificial vertebral lamina. [J]. Journal of Chongqing Medical University (4):489-493(2006)
[1]肖智博,吕富荣,吕发金,蒋电明,唐文胜.纳米羟基磷灰石/聚酰胺复合材料预防椎板切除后椎管狭窄、粘连的初步影像研究[J].重庆医科大学学报,2006(04):489-493. DOI：

XIAO Zhibo, et al. An tentative radiological and basical studies of preventing the constriction after the laminectomy by using the nano-hydroxyapatite/polyamide-66 composite material artificial vertebral lamina. [J]. Journal of Chongqing Medical University (4):489-493(2006) DOI：

摘要

目的:探讨影像学关于纳米羟基磷灰石/聚酰胺复合材料（n-HA/pA66）在预防椎板切除后并发症的表现

通过病理对照研究来提供临床指导。方法:建立22只家犬L5椎板切除实验模型

随机分成实验组和对照组。术后行CR和MRI扫描等影像方法与组织学的检测。结果:X线结果术后8周人工椎板与骨接触面开始模糊

至术后24周人工椎板与骨接触界面消失

密度增高

钙化;而对照组始终表现为腰5椎板棘突缺损

无致密影出现。组织学结果术后8周人工椎板内层的纤维组织-材料界面就出现较多成骨细胞团及骨小梁;对照组椎板缺损处是纤维瘢痕逐步形成

最终与硬膜粘连。MRI对脊髓受压及硬膜粘连情况显示较好

实验节段与对照节段相比

椎管面积及矢状径有明显差异（P<0.05）。显示出重建椎板节段椎管完整性得到恢复

与组织学一致。结论:n-HA/PA66复合材料能够阻止硬膜外粘连

X线及MRI对其检测准确、全面。

Abstract

Objective: To discuss the radiological evaluation after the experiment implanted artificial vertebral lamina made from n-HA/PA66 into the defect of vertebral lamina

in order to evaluate its value in preventing the complication of postlaminectomy.Methods:22 male dogs aged one year were classified randomly into three groups: the experimental group(13 dogs)and the control group(9 dogs).The specimens were examined by the methods of plain roentgenography

MRI and histology.Results:The X-ray: in the experimental group

it was becoming cloudy around the operative area in the 8th week;till 24th week

the density of the operative area was the same with the density of bone.The histology: in the experimental group

from the 8th week

there were many cartilage cells and lamellar bone observed.While in the control group

it was just fibrous layer forming.MRI:the reconstructed segment after the laminoplasty was detected clearly by MRI

which coincided with the histology.Compared with the control segment

the numbers of the area of vertebral canal and the sagital axis were significantly different(P<0.05).Conclusion: The experimental results show that n-HA/PA66 composite material not only has the attribute of good biocompatibility

but also can effectively prevent the scar formation and adhesion.

which can be detected by the X-ray and MRI exactly.

关键词

纳米羟基磷灰石聚酰胺66人工椎板椎板切除磁共振成像

Keywords

Nano-hydroxyapatitePolyamide-66Artificial vertebral laminaLaminectomyMRI

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