Objective: To screen angiogenesis inhibitor from 26 drugs for promoting blood circulation and removing blood stasis through chick chorioallantoic membrane(CAM)model in vivo.Methods: The experimental groups were 26 drugs for promoting blood circulation and removing blood stasis.Tablets

capsules

pills and powder of the drugs were adopted in the form of saturated concentration

decoction was in the form of concentration of 2g/ml

and injection

oral liquid and electuary were in their own concentration.7-day-old fertilized white chicken eggs incubated at 37℃ in chamber were prepared by creating a window in the shell.A sponge carrier was placed on CAM and treated with different liquid medicine with the dosage of 20μl per egg daily for 3 days.On day 10

the number of CAM blood vessel embranchment 5mm around the carrier was counted with a stereomicroscope.Results: 15 drugs for promoting blood circulation and removing blood stasis obviously inhibited the CAM blood vessels(P<0.05).Conclusion: Elemene Emulsion

Zedoary Turmeric Oil and Glucose injection

Ligustrazine Phosphate injection

Sodium Ferulate for injection

Tripterygium Glycosides

Huoba Huagen tablet

Zushima tablet

Fufang Banmao capsule

Dahuang Zhechong pill

Dahuoluo pill

Qili powder

Huoxue Tongmai tablet

Fufang Danshen drop pill

Shanleng pill and Taohong Siwu decoctionⅡhave a potential effect on antiangiogenisis.