The relation between expression of MMP-9/TIMP-1 in the implantation window phase of endometrium and estrodial and progesteron

GUI Wenwu; et al

您当前的位置：

首页 >

文章列表页 >

The relation between expression of MMP-9/TIMP-1 in the implantation window phase of endometrium and estrodial and progesteron

更新时间：2024-01-17

- The relation between expression of MMP-9/TIMP-1 in the implantation window phase of endometrium and estrodial and progesteron
- Journal of Chongqing Medical University Issue 3, Pages: 358-360(2006)
- 作者机构：
  
  1. 重庆医科大学附属第一医院妇产科辅助生殖中心
  2. 重庆医科大学附属第一医院妇产科辅助生殖中心,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R714
- Published：2006，
扫描看全文
[1]桂文武,丘彦,幸贵邦,周永芳,王炼炼,熊秀梅.子宫内膜种植窗期基质金属蛋白酶-9及其抑制物-1的表达与雌孕激素关系[J].重庆医科大学学报,2006(03):358-360+365.

GUI Wenwu, et al. The relation between expression of MMP-9/TIMP-1 in the implantation window phase of endometrium and estrodial and progesteron. [J]. Journal of Chongqing Medical University (3):358-360(2006)
[1]桂文武,丘彦,幸贵邦,周永芳,王炼炼,熊秀梅.子宫内膜种植窗期基质金属蛋白酶-9及其抑制物-1的表达与雌孕激素关系[J].重庆医科大学学报,2006(03):358-360+365. DOI：

GUI Wenwu, et al. The relation between expression of MMP-9/TIMP-1 in the implantation window phase of endometrium and estrodial and progesteron. [J]. Journal of Chongqing Medical University (3):358-360(2006) DOI：

摘要

目的:探讨内膜种植窗期基质金属蛋白酶-9（MMP-9）及组织金属蛋白酶抑制物-1（TIMP-1）与血清雌孕激素的关系。方法:选择排卵正常妇女的种植窗期子宫内膜31例

同时抽取其静脉血;用免疫组化法检测种植窗期子宫内膜组织中MMP-9/TIMP-1蛋白的表达;测定种植窗期血清雌（E2）、孕激素（P）值。分析MMP-9/TIMP-1蛋白分别与血清E2、P的相关性。结果:种植窗期子宫内膜组织中MMP-9/TIMP-1蛋白表达的光密度值分别为:0.163±0.025、0.143±0.015;同期血清E2、P值分别为:182.153±45.774pg/ml、22.997±6.697ng/ml;MMP-9与血清P呈负相关性（P<0.001）

TIMP-1与P无相关性（P>0.05）;MMP-9/TIMP-1与血清E2均无相关性（P>0.05）。结论:MMP-9与血清P呈负相关

TIMP-1与P无相关性。MMP-9/TIMP-1与血清E2均无相关性。

Abstract

Objective: To study the relation between the expression of matrix metalloproteinase-9(MMP-9) / tissue inhibitor of metalloproteinase-1(TIMP-1) protein in the implantation window endometrium phase and serum estradiol and progesterone.Methods: 31 women with regular ovulation were included to obtain endometrium samples in implantation window phase

and at the same time serum were abstracted from vein for E2 and P testing.Immunohistochemical analysis was applied to measure the expression of MMP-9/TIMP-1 protein in the implantation window.Analysis the correlationship between MMP-9/TIMP-1 and E2 and P.Results: The light dense of the expression of MMP-9 / TIMP-1 protein in the endometrium of implantation window were 0.163±0.025

0.143±0.015 respectively

and the corresponding serum E2

P were 182.153±45.774pg/ml

22.997±6.697ng/ml respectively.There was negative correlationship between MMP-9 and P(P<0.001)

no correlationship was found between TIMP-1 and P

neither was MMP-9/TIMP-1 and E2.Conclusion: MMP-9 and P were correlated negatively

however there was no correlationship were found between TIMP-1and P

and between MMP-9/TIMP-1 and E2.

关键词

MMP-9TIMP-1种植窗雌激素孕激素

Keywords

matrix metalloproteinase-9Tissue inhibitor of metalloproteinase-1Plantation windowestradiolprogesterone

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 protein in the implantation window phase of endometrium in ovulation normal women

Investigation into the effect and mechanism of Hedgehog signaling pathway on invasion and migration of human gastric cancer cell line SGC-7901

Expression of thyroid autoimmune antibodies and its correlation with serum estradiol level and estradiol-to-progesterone ratio in patients with polycystic ovary syndrome

Effects of estrogen and progesterone on expressions of connexin26，connexin32 and connexin43 in nude mice model of endometriosis

Related Author

GUI Wenwu

et al

曾品鸿

刘淑文

舒为群

OUYANG Xiao-bo

et al

王立

Related Institution

Department of Obstetrics and Gynecology,College of Clinical Medicine,Chongqing Medical University

重庆医科大学临床学院妇产科辅助生殖中心

Department of Gastroemerology,the First Affiliated Hospital,Chongqing Medical University

Department of Endocrinology and Metabolism，The First Hospital of China Medical University

Department of Obstetrics and Gynecology，University-Town Hospital of Chongqing Medical University

⁰