Clinical study of immunoregulation therapy in the patients with severe trauma,sepsis or mods

HUANG Youcheng; et al

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Clinical study of immunoregulation therapy in the patients with severe trauma,sepsis or mods

更新时间：2024-01-17

- Clinical study of immunoregulation therapy in the patients with severe trauma,sepsis or mods
- Journal of Chongqing Medical University Issue 5, Pages: 739-741(2006)
- 作者机构：
  
  1. 重庆医科大学附属第一医院普外科
  2. 重庆医科大学附属第一医院普外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R631;R641
- Published：2006，
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[1]黄有成,代远斌.严重创伤、脓毒症和MODS免疫调理治疗的临床研究[J].重庆医科大学学报,2006(05):739-741+765.

HUANG Youcheng, et al. Clinical study of immunoregulation therapy in the patients with severe trauma,sepsis or mods. [J]. Journal of Chongqing Medical University (5):739-741(2006)
[1]黄有成,代远斌.严重创伤、脓毒症和MODS免疫调理治疗的临床研究[J].重庆医科大学学报,2006(05):739-741+765. DOI：

HUANG Youcheng, et al. Clinical study of immunoregulation therapy in the patients with severe trauma,sepsis or mods. [J]. Journal of Chongqing Medical University (5):739-741(2006) DOI：

摘要

目的:研究对严重创伤、脓毒症和MODS进行免疫调理治疗的可行性。方法:24例患者随机分成对照组（A）与治疗组（B）

对照组常规治疗

治疗组常规治疗加胸腺肽α（迈普欣）和乌司他丁

疗程为7天

观察期28天。结果:治疗组CD14+单核细胞HLA-DR表达率治疗前后差异有统计学意义（P<0.05）;并且TNF-α、IL-6、APACHEⅡ评分显著降低。结论:联用迈普新（胸腺肽α）和乌司他丁治疗严重脓毒症、MODS可显著降低TNF-α及IL-6的水平

可提高患者免疫力

改善患者的预后;对严重脓毒症、MODS采用免疫调理治疗具有可行性。

Abstract

Objective:To study the feasibility of immunomodulation on the patients with severe trauma

sepsis or MODS.Methods:24 patients were divided into control group(A) and therapy group(B) randomly.The control group was given routine therapy while the therapy group was treated with Ulinastatin and thymosin-α1 for 7 days additionally

and two groups were observed for 28 days.Results:Compared with the control group

the expression of CD14+ monocyte HLA-DR in the therapy group increased significantly

while the levels of TNF-α

IL-6 and APACHE Ⅱ score in the therapy group decreased significantly.Conclusions:Treating the patients with thymosin-α1 and Ulinastatin could decrease the levels of TNF-α and IL-6

raise their immunity and improve their prognosis.Immunoregulation treatment is effective for patients with severe sepsis and MODS.

关键词

脓毒症多器官功能不全综合征CD14+单核细胞HLA-DR免疫调理

Keywords

sepsisMultiple organ dysfunction syndrome(MODS)CD14+monocyte HLA-DRImmunomodulation

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