Protection of little dosage of Desamethasone to pulmonary function on acute lung injury model

LIANG Ling

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Protection of little dosage of Desamethasone to pulmonary function on acute lung injury model

更新时间：2024-01-17

- Protection of little dosage of Desamethasone to pulmonary function on acute lung injury model
- Journal of Chongqing Medical University Issue 5, Pages: 747-749(2006)
- 作者机构：
  
  深圳市平湖人民医院药剂科,深圳,518111
- 作者简介：
- 基金信息：
- DOI：
  CLC： R96
- Published：2006，
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[1]梁玲.创建急性肺损伤模型探讨小剂量地塞米松对肺脏的保护作用[J].重庆医科大学学报,2006(05):747-749.

LIANG Ling. Protection of little dosage of Desamethasone to pulmonary function on acute lung injury model. [J]. Journal of Chongqing Medical University (5):747-749(2006)
[1]梁玲.创建急性肺损伤模型探讨小剂量地塞米松对肺脏的保护作用[J].重庆医科大学学报,2006(05):747-749. DOI：

LIANG Ling. Protection of little dosage of Desamethasone to pulmonary function on acute lung injury model. [J]. Journal of Chongqing Medical University (5):747-749(2006) DOI：

摘要

目的:探讨小剂量地塞米松对急性肺损伤动物模型肺脏的保护作用。方法:雄性SD大鼠54只

随机平均分为对照组、损伤组和激素组。主要观察指标:支气管肺泡灌洗液细胞总数计数、总蛋白水平、TNF-α水平。次要指标:肺系数、动脉血氧分压、血清中TNF-α的变化及病理检查结果。结果:激素组肺泡结构仍存在

但肺泡间隔增厚

中性粒细胞浸润明显减轻

肺泡腔内见少量渗出;激素组大鼠的动脉血氧分压明显高于损伤组（P<0.05）。激素组的大鼠肺系数及支气管肺泡灌洗液的总蛋白水平、细胞总数与其他组比较有显著性差异（P<0.05）;激素组第2h血清中和第2、6h支气管肺泡灌洗液中TNF-α水平与其他组比较有显著性差异（P<0.05）。结论:小剂量地塞米松对肺组织损伤有一定保护作用。

Abstract

Objective:To explore the pretection of small dosage desamethasone to pulmonary function on acute lung injury model.Methods:54 male SD rats were divided randomly into control group

injury group and therapeutic group.Major observed marker consisted of count of cell sum

total protein level and TNF-α level of bronchoalveolar douche solution.Secondary marker consisted of lung coefficient

PAO2

TNF-α level in blood serum and histopathologic examination.Results: Alveolar texture in therapeutic group existed yet

but alveolar interval increased thickness

neutrophilic granulocyte infiltration relieved obviously

and a little bleeding in alveolar cavity.PAO2 in therapeutic group was higher than that of injured group(P <0.05).A significant difference existed between therapeutic group and other groups in lung coefficient

total protein level and cell sum of bronchoalveolar douche solution(P <0.05).and a obvious difference in TNF-α level also existed between therapeutic group and other groups in blood serum in 2 hours and in bronchoalveolar douche solution in 2 and 6 hours(P<0.05).Conclusion: Small dosage desamethasone could protect injured lung texture.

关键词

急性肺损伤地塞米松肺功能

Keywords

acute lung injuryDesamethasonepulmonary function

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