Establishment of acute Respiratory distress syndrome model in beagle dogs

DU Yong hong; et al

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Establishment of acute Respiratory distress syndrome model in beagle dogs

更新时间：2024-01-17

- Establishment of acute Respiratory distress syndrome model in beagle dogs
- Journal of Chongqing Medical University Issue 5, Pages: 649-651(2006)
- 作者机构：
  
  1. 重庆医科大学生物医学工程系医学超声工程研究所
  2. 重庆医科大学附属第二医院
- 作者简介：
- 基金信息：
- DOI：
  CLC： R-332
- Published：2006，
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[1]杜永洪,王导新,陈文直,黎克全,魏安宁,胡凯,白晋,王智彪.Beagle犬急性呼吸窘迫综合征模型的建立[J].重庆医科大学学报,2006(05):649-651+693.

DU Yong hong, et al. Establishment of acute Respiratory distress syndrome model in beagle dogs. [J]. Journal of Chongqing Medical University (5):649-651(2006)
[1]杜永洪,王导新,陈文直,黎克全,魏安宁,胡凯,白晋,王智彪.Beagle犬急性呼吸窘迫综合征模型的建立[J].重庆医科大学学报,2006(05):649-651+693. DOI：

DU Yong hong, et al. Establishment of acute Respiratory distress syndrome model in beagle dogs. [J]. Journal of Chongqing Medical University (5):649-651(2006) DOI：

摘要

目的:探讨用油酸建立Beagle犬急性呼吸窘迫综合征（ARDS）模型的可行性、稳定性。方法:25只Beagle犬麻醉保定后

通过颈静脉

按0.25±0.03ml/kg缓慢注射油酸

连续监测肺气体交换指标、氧代谢、组织病理学和胸片的改变

以及达到ARDS的诊断标准后各项指标的稳定性。结果:颈静脉泵入油酸后4.16±0.92h

25只Beagle犬达到ARDS诊断标准

其动脉血PaCO227.98±8.25mmHg、PaO2 65.40±11.48mmHg、PaO2/FiO2 182.3±29.6

经呼吸机机械通气治疗

PaO2/FiO2≤200。光镜下见肺间质及肺泡水肿、出血、萎陷和透明膜形成

同时伴炎症细胞浸润。胸片见双侧肺部有浓密或磨玻璃样阴影。结论:通过颈静脉注射油酸

可快速复制血流动力学、肺机械力学、组织病理学改变等均稳定的Beagle犬ARDS动物模型。

Abstract

Objective:To explore the feasibility and stability of using oleic acid to establish acute respiratory distress syndrome(ARDS) model in Beagle dogs.Methods:A total of 25 Beagle dogs were injected oleic acid with a speed of 0.25±0.03ml/Kg through jugular vein after being anesthetized.The gas ventilation index

oxygen metabolism

histopathological changes

chest-ray scan and stability of each index after establishing the ARDS situation were continuously monitored and evaluated.Results:All 25 dogs were reached the diagnosis criteria of ARDS in 4.16±0.92 hours after injection of oleic acid

The arterial PaCO2 of the animals was 27.98±8.25mmHg

PaO2 was 65.40±11.48mmHg

and PaO2/FiO2 was 182.3±29.6.After mechanical ventilation treatment

PaO2/FiO2≤200.Pulmonary mesenchyme

and alveolus edema

bleeding

shrinkage and transparent formation were seen under microscope.There was darkness or coarse shadow in the lung by the X-ray scan.Conclusions:Through injection of oleic acid via jugular vein

a Beagle dog ARDS model may be quickly established with stable changes of hemodynamics

pulmonary mechanics and histology.

关键词

呼吸窘迫综合征油酸动物模型Beagle犬

Keywords

Acute respiratory distress syndromeOleic acidanimal modelBeagle dog

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