Effects of lycium barbarum polysaccharide on the expression of hepatocyte cytochrome P4502E1 in rats with alcoholic fatty liver

GU Sai; et al

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Effects of lycium barbarum polysaccharide on the expression of hepatocyte cytochrome P4502E1 in rats with alcoholic fatty liver

更新时间：2024-01-17

- Effects of lycium barbarum polysaccharide on the expression of hepatocyte cytochrome P4502E1 in rats with alcoholic fatty liver
- Journal of Chongqing Medical University Issue 5, Pages: 688-693(2006)
- 作者机构：
  
  1. 重庆医科大学附属第一医院消化内科
  2. 重庆医科大学组胚教研室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R285
- Published：2006，
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[1]古赛,王丕龙,姜蓉.枸杞多糖对酒精性脂肪肝大鼠肝细胞色素P4502E1基因及蛋白表达的影响[J].重庆医科大学学报,2006(05):688-693.

GU Sai, et al. Effects of lycium barbarum polysaccharide on the expression of hepatocyte cytochrome P4502E1 in rats with alcoholic fatty liver. [J]. Journal of Chongqing Medical University (5):688-693(2006)
[1]古赛,王丕龙,姜蓉.枸杞多糖对酒精性脂肪肝大鼠肝细胞色素P4502E1基因及蛋白表达的影响[J].重庆医科大学学报,2006(05):688-693. DOI：

GU Sai, et al. Effects of lycium barbarum polysaccharide on the expression of hepatocyte cytochrome P4502E1 in rats with alcoholic fatty liver. [J]. Journal of Chongqing Medical University (5):688-693(2006) DOI：

摘要

目的:通过观察枸杞多糖（LBP）对酒精性脂肪肝（AFL）大鼠肝细胞色素P4502E1基因和蛋白的影响

揭示其治疗机制。方法:用乙醇灌胃10周造成大鼠慢性AFL模型

再用5%、10%LBP和10%阿托莫兰（GSH）治疗10周

戒酒组为阳性对照

作治疗前后比较:肝脏病理形态

肝匀浆还原型谷光甘肽GSH、丙二醛MDA含量

肝细胞色素P4502E1（CYP2E1）基因及蛋白表达水平。结果:LBP能明显改善酒精所致大鼠肝脏脂肪性病理变化

增加GSH含量

减少MDA产生

抑制CYP2E1基因及蛋白表达水平

与阿托莫兰组无显著差异

优于单纯戒酒组。结论:LBP抑制CYP2E1基因及蛋白表达

减轻脂质过氧化作用

有效的治疗AFL。

Abstract

Objective:To study the effect of Lycium Barbarum Pclysaccharide(LBP)on the expression of hepatocyte cytochrome P4502E1(CYP2E1) in rat model of alcoholic fatty liver(AFL).Methods: The AFL rats models were established by ethanol intragastric infusion in ten weeks

then

5% and 10% LBP and 10% GSH intragastric infusions were adopted to treat those AFL model rats.Liver pathologic changes were observed and CYP2E1 gene and protein expressions as well as the contents of malondialdehyde(MDA) and glutathione(GSH) in liver were detected and compared with those in the control group

treatment groups and abstinence treatment group.Results: Fatty degeneration in liver recovered normally in the LBP-treated groups.LBP could inhibit the expressions of CYP2E1 gene and protein

reduce the content of MDA

and increase the content of GSH.The curative effect of LBP was of no significant difference compared with GSH

but had more effect than abstinence treatment.Conclusion: LBP can prevent AFL though inhibiting the hepatocyte CYP2E1 expression markedly.

关键词

酒精性脂肪肝枸杞多糖治疗细胞色素P4502E1

Keywords

alcoholic fatty liverLyceum Barbarum PolysaccharidetreatmentCytochrome P450

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Related Institution

Department of Gastroenterology,the First Affilated Hospital,Chongqing Medical University

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