The apoptosis and expression of apoptosis related proteins in the developing mouse stomach

LIN Xuemei; et al

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The apoptosis and expression of apoptosis related proteins in the developing mouse stomach

更新时间：2024-01-17

- The apoptosis and expression of apoptosis related proteins in the developing mouse stomach
- Journal of Chongqing Medical University Issue 2, Pages: 200-203(2006)
- 作者机构：
  
  1. 重庆医科大学基础医学院组织与胚胎学教研室
  2. 重庆市急救中心
- 作者简介：
- 基金信息：
- DOI：
  CLC： Q954.48
- Published：2006，
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[1]林雪梅,李均,汪维伟.小鼠胚胎胃发育中细胞凋亡及凋亡相关蛋白的表达[J].重庆医科大学学报,2006(02):200-203.

LIN Xuemei, et al. The apoptosis and expression of apoptosis related proteins in the developing mouse stomach. [J]. Journal of Chongqing Medical University (2):200-203(2006)
[1]林雪梅,李均,汪维伟.小鼠胚胎胃发育中细胞凋亡及凋亡相关蛋白的表达[J].重庆医科大学学报,2006(02):200-203. DOI：

LIN Xuemei, et al. The apoptosis and expression of apoptosis related proteins in the developing mouse stomach. [J]. Journal of Chongqing Medical University (2):200-203(2006) DOI：

摘要

目的:观察小鼠胚胎胃发育过程中上皮细胞凋亡及凋亡相关蛋白Bcl-2、Bax、P53的表达。方法:E11d～E15d胎鼠连续切片

体视学法测量胃上皮凋亡小体密度（DAB）;免疫组化SABC法检测凋亡相关蛋白Bcl-2、Bax、P53的表达。结果:①胃DAB峰值为E14d～E15d。②Bcl-2表达峰值为E11～13d;Bax表达峰值在E14d

P53表达峰值在E11～13d。结论:Bcl-2可能具有抑制胃上皮细胞凋亡的作用;Bax可能具有促进细胞凋亡的作用;P53可能与胃上皮细胞凋亡调控的关系不密切。

Abstract

Objective: To observe the apoptosis and expression of apoptosis related proteins Bcl-2

Bax and P53 during the developing mouse stomach.Methods: Serial sections of fetal mice aged 11～15 days were made.The density of apoptotic bodies(DAB) in the epithelium was measured with stereological method.The expression of apoptosis related proteins Bcl-2

Bax and P53 in the epithelium were detected with the SABC method of immunocytochemistry

and image analysier was used to detect the products-intensity of each section.Results: ① The peak-expression of DAB in the epithelium was on the 14 th and 15 th day.② The peak-expression of Bcl-2 in the epithelium was on the 11 th and 13 th day

the peak-expression of Bax in the epithelium was on the 14 th day

the peak-expression of P53 were on the 11 th and 14 th day.Conclusion: ① Bcl-2 may have a role in suppressing cell apoptosis in the epithelium of stomach

Bax may have a role in promoting cell apoptosis.P53 do not have close relationship with the control of epithelial cells apoptosis in fetus mouse stomach.

关键词

胎鼠胃细胞凋亡凋亡相关蛋白

Keywords

Fetus mousestomachcell apoptosisProtein expression

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