The association of a TA repeat polymorphism in ERa gene with unknown aetiology hypomenorrhea

YUAN Rui; et al

您当前的位置：

首页 >

文章列表页 >

The association of a TA repeat polymorphism in ERa gene with unknown aetiology hypomenorrhea

更新时间：2024-01-17

- The association of a TA repeat polymorphism in ERa gene with unknown aetiology hypomenorrhea
- Journal of Chongqing Medical University Issue 5, Pages: 697-700(2006)
- 作者机构：
  
  1. 重庆医科大学附属第一医院妇产科
  2. 重庆医科大学附属第一医院妇产科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R711.5
- Published：2006，
扫描看全文
[1]袁瑞,乐爱文,耿力,周晓曦,姚珍薇.雌激素受体α基因TA重复序列多态性与原因不明月经过少的关系[J].重庆医科大学学报,2006(05):697-700.

YUAN Rui, et al. The association of a TA repeat polymorphism in ERa gene with unknown aetiology hypomenorrhea. [J]. Journal of Chongqing Medical University (5):697-700(2006)
[1]袁瑞,乐爱文,耿力,周晓曦,姚珍薇.雌激素受体α基因TA重复序列多态性与原因不明月经过少的关系[J].重庆医科大学学报,2006(05):697-700. DOI：

YUAN Rui, et al. The association of a TA repeat polymorphism in ERa gene with unknown aetiology hypomenorrhea. [J]. Journal of Chongqing Medical University (5):697-700(2006) DOI：

摘要

目的:研究雌激素受体a（estrogen receptor a

ERa）基因二核苷酸重复序列多态性与原因不明月经过少关系。方法:选择西南地区的100名月经正常者作为对照组

100名原因不明月经过少患者为病例组。同时对她们雌激素受体基因上游的高变区二核苷酸（TA）重复序列进行纯化、克隆和序列分析

阐明该重复序列的重复多态性在实验组与对照组当中的分布情况及与原因不明月经过少的关系。结果:共分离出7种等位基因

其（TA）n重复数目为11至17

对照组中最常见的等位基因为TA14

正常组和病例组的（TA）n重复序列等位基因的分布频率不同

差异有显著性（χ2=13.412

P=0.037）。再用Fisher’s确切概率法比较两组病人各等位基因的分布频率

病例组TA13等位基因频率高于对照组

差异有显著性（P=0.006）

TA15等位基因频率低于对照组

差异有显著性（P=0.033）。结论:ERa基因TA多态性与原因不明月经过少有关

TA13等位基因可能是原因不明月经过少的危险因素;TA15等位基因可能是其保护因素。

Abstract

Objective:To investigate the association of a(TA)n dinucleotide repeat polymorphism with unknown aetiology hypomenorrhea.Methods:100 normal menstruation person(control group) and 100 hypomenorrhea patients(case group)were recruited.they all came from southen-western China.The(TA)n dinucleotide repeat in ERa gene upstream hypervariable region were purifed

cloned and sequence analysed.we observe the ERa gene(TA)n dinucleotide repeat polymorphism distribution in the two groups.Results:All samples exhibted 7 different alleles.The(TA)n dinucleotide repeats were 11~17

The most prevalent allele was TA14 repeat in control group.The distribution of the different alleles of the(TA)n dinucleotide repeat sequence in the group and control group has significant difference(χ2=13.412

P =0.037).Fisher’s exact test was applied to compare the frequency of each a1lele between two groups.The frenquency of the TA13 allele was found to be significantly greater in hypomenorrhea group(P =0.006)

and the frenquency of the TA15 allele was less in the group(P =0.033).Conclusion:A(TA)n dinucleotide repeat sequence which is in ERa gene upstream hypervariable region was associated with unknown aetiology hypomenorrhea.The TA13 allele was found to be associated with unknown aetiology hypomenorrhea and may be a risk factor;whereas TA15 allele may be a protective factor for patients.

关键词

月经过少雌激素受体二核苷酸（TA）重复序列多态性等位基因

Keywords

Hypomenorrheaestrogen receptor(TA) dinucleotide repeat sequencepolymorphismAllele

references

Views

116

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

The association of a CA repeat polymorphism in ERβ gene with unknown aetiology hypomenorrhea

Association between norepinephrine transporter T182C polymorphism and depression:a Meta-analysis

Effect of different dosages of estrogen on ovarian function and ESR1 expression after hysteroscopic adhesiolysis

CORRELATION OF ESTROGEN RECEPTOR CONTENT AND MORPHOMETRIC ULTRA-STRUCTURE OF BREAST CANCER

The observation of androgen receptor and estrogen receptor in hepatocellular carcinomas with immunoelectron - microscopy

Related Author

夏恩兰

et al

LE Aiwen

Liu Wenqin

Deng Zhilin

Liu Jing

Wang Hanyan

Zhou Qin

Related Institution

首都医科大学附属复兴医院宫腔镜中心

Department of Imaging,North Sichuan Medical College

Teaching and Research Section of Biochemistry,School of Basic Medical Sciences

Department of Obstetrics and Gynecology,The First Affiliated Hospital of Chongqing Medical University

重庆医科大学电镜室

⁰