Expression and clinical significance of survivin, bcl-2 and mdr1 in acute leukemia in children

LIU Xiaomei; et al

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Expression and clinical significance of survivin, bcl-2 and mdr1 in acute leukemia in children

更新时间：2024-01-17

- Expression and clinical significance of survivin, bcl-2 and mdr1 in acute leukemia in children
- Journal of Chongqing Medical University Issue 2, Pages: 215-218(2006)
- 作者机构：
  
  1. 重庆医科大学附属儿童医院血液肿瘤科
  2. 重庆医科大学附属儿童医院血液肿瘤科,重庆,400014
- 作者简介：
- 基金信息：
- DOI：
  CLC： R733.71
- Published：2006，
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[1]刘筱梅,徐酉华,于洁,邓兵,苏庸春.儿童急性白血病survivin,bcl-2,mdr1的表达及意义[J].重庆医科大学学报,2006(02):215-218+226.

LIU Xiaomei, et al. Expression and clinical significance of survivin, bcl-2 and mdr1 in acute leukemia in children. [J]. Journal of Chongqing Medical University (2):215-218(2006)
[1]刘筱梅,徐酉华,于洁,邓兵,苏庸春.儿童急性白血病survivin,bcl-2,mdr1的表达及意义[J].重庆医科大学学报,2006(02):215-218+226. DOI：

LIU Xiaomei, et al. Expression and clinical significance of survivin, bcl-2 and mdr1 in acute leukemia in children. [J]. Journal of Chongqing Medical University (2):215-218(2006) DOI：

摘要

目的:探讨急性白血病患儿survivin、bcl-2、mdr1 mRNA表达及临床意义。方法:用RT-PCR的方法检测患儿骨髓survivin、bcl-2和mdr1的mRNA。结果:初诊患儿survivin、bcl-2和mdr1的阳性表达率高于对照组。初诊急性淋巴细胞性白血病和急性髓细胞性白血病survivin、bcl-2、mdr1阳性表达率无显著性差异。完全缓解期患儿survivin和bcl-2阳性表达明显低于初诊白血病患儿。复发组survivin、bcl-2、mdr1三者阳性率明显高于缓解组。survivin阳性和阴性表达者外周血白细胞总数无显著性差异（P>0.05）。结论:survivin和bcl-2在急性白血病患儿表达增高

其表达与急性白血病的类型和外周血白细胞总数无关。survivin、bcl-2和mdr1在儿童白血病的共表达可能提示预后不良。

Abstract

Objective: To explore the expression of survivin

bcl-2 and mdr1 in acute leukemia in children and its clinical significance.Methods: The mRNA of survivin

bcl-2 and mdr1 in all patients were detected by RT-PCR.Results: The positive expression rates of survivin

bcl-2 and mdr1 in the newly diagnosed group were 60.47%(26/43N)

60.47%(26/43N) and 34.88%(15/43N)

respectively

all of which were higher than those in the control group(P<0.05).There was no significant difference in the positive expression of survivin

bcl-2 and mdr1 between acute lymphocytic leukemia(ALL) and acute myeloid leukemia(AML) group(P>0.05).The positive expression rates of survivin and bcl-2 in the CR group were significant lower than those in the newly diagnosed group(P<0.05).There were 3 patients and 2 patients with positive co-expression of survivin

bcl-2 and mdr1 in newly diagnosed group and RE group respectively.The WBC was not significantly different between positive survivin and negative survivin group(P>0.05).Conclusions: survivin

bcl-2 and mdr1 have higher expression in children with AL

which may contribute to the pathogenesis and the progress of the leukemia.The expression of survivin and bcl-2 is not related to the type of leukemia and the WBC.The co-expression of survivin bcl-2 and mdrl may indicate the poor prognosis of leukemia in children.

关键词

SurvivinBcl-2mdr1白血病儿童

Keywords

SurvivinBcl-2mdr1leukemiachildren

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