Fetal rats arrhythmias in intrahepatic cholestasis of pregnancy

SHAO Yong; et al

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Fetal rats arrhythmias in intrahepatic cholestasis of pregnancy

更新时间：2024-01-17

- Fetal rats arrhythmias in intrahepatic cholestasis of pregnancy
- Journal of Chongqing Medical University Issue 2, Pages: 236-239(2006)
- 作者机构：
  
  1. 重庆医科大学附属第一医院妇产科
  2. 重庆医科大学生理教研室
  3. 重庆医科大学附属第一医院妇产科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R714.2
- Published：2006，
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[1]邵勇,姚珍薇,陆杰,罗红霞,吴味辛.孕鼠肝内胆汁淤积症致胎鼠心律失常的实验研究[J].重庆医科大学学报,2006(02):236-239.

SHAO Yong, et al. Fetal rats arrhythmias in intrahepatic cholestasis of pregnancy. [J]. Journal of Chongqing Medical University (2):236-239(2006)
[1]邵勇,姚珍薇,陆杰,罗红霞,吴味辛.孕鼠肝内胆汁淤积症致胎鼠心律失常的实验研究[J].重庆医科大学学报,2006(02):236-239. DOI：

SHAO Yong, et al. Fetal rats arrhythmias in intrahepatic cholestasis of pregnancy. [J]. Journal of Chongqing Medical University (2):236-239(2006) DOI：

摘要

目的:探讨孕鼠肝内胆汁淤积症致胎鼠心电图的异常。方法:应用雌、孕激素建立妊娠肝内胆汁淤积症大鼠模型

通过Powerlab生物信号处理系统Chart 5软件引导妊娠第20天和第21天胎鼠宫内心电图。结果:（1）妊娠第20天

胆淤模型组1孕鼠血清总胆汁酸（TBA）水平为（64.3±5.2）μmol/L;妊娠第21天

胆淤模型组2孕鼠血清总胆汁酸（TBA）水平为（78.5±4.5）μmol/L。两组比较差异有极显著性

P<0.01。（2）妊娠第20天

胆淤模型组1持续观察90min

胎鼠心电图均显示正常;妊娠第21天

胆淤模型组2实验开始时胎鼠心电图正常

持续观察29.3±6.4min后出现胎鼠心律不齐

继续观察23.5±4.6min后胎鼠死亡

而正常对照组2持续观察90min

胎鼠心电图均正常。结论:孕鼠肝内胆汁淤积症时胎鼠死亡前出现短暂的心律失常阶段。

Abstract

Objective: To investigate fetal rats abnormal electrocardiograms in intrahepatic cholestasis of pregnancy(ICP).Methods: The animal model of intrahepatic cholestasis of pregnancy was induced by 17-α-Ethinylestradiol and Progesterone.The electrocardiograms of fetal rats by conceptual day 20th(Group1)

day 21st(Group2) were evaluated with Powerlab biologic signal extracting and analyzing system Chart 5 Software.Results: ①The serum total bile acids(TBA) levels of pregnant rats of ICP were 64.3±5.2(μmol/L) in group 1

78.5±4.5(μmol/L) in group 2

respectively

which showed significant differences(P<0.01).②It showed all normal electrocardiograms of fetal rats in Group1 over 90 minutes continuous observation.In Group2

fetal rats arrhythmias appeared after 29.3±6.4 minutes normal electrocardiograms observed initially;About 23.5±4.6(range 15-30)minutes fetal rats arrhythmias later

fatal ventricular arrhythmias came out and the fetal rats died suddenly.Conclusion: It demonstrated that fetal arrhythmias contribute to fetal sudden death in ICP.

关键词

肝内胆汁淤积症妊娠心律失常猝死

Keywords

Intrahepatic cholestasis of pregnancyArrhythmiassudden death

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