Expression and clinical significance of Rb gene and MCM2 in prostate cancer

LI Yunxiang; et al

您当前的位置：

首页 >

文章列表页 >

Expression and clinical significance of Rb gene and MCM2 in prostate cancer

更新时间：2024-01-17

- Expression and clinical significance of Rb gene and MCM2 in prostate cancer
- Journal of Chongqing Medical University Issue 1, Pages: 66-69(2006)
- 作者机构：
  
  1. 重庆医科大学附属第一医院泌尿外科
  2. 重庆医科大学附属第一医院泌尿外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.25
- Published：2006，
扫描看全文
[1]李云祥,苟欣,张世卿,何卫阳.Rb和MCM2蛋白在前列腺癌中的表达及临床意义[J].重庆医科大学学报,2006(01):66-69.

LI Yunxiang, et al. Expression and clinical significance of Rb gene and MCM2 in prostate cancer. [J]. Journal of Chongqing Medical University (1):66-69(2006)
[1]李云祥,苟欣,张世卿,何卫阳.Rb和MCM2蛋白在前列腺癌中的表达及临床意义[J].重庆医科大学学报,2006(01):66-69. DOI：

LI Yunxiang, et al. Expression and clinical significance of Rb gene and MCM2 in prostate cancer. [J]. Journal of Chongqing Medical University (1):66-69(2006) DOI：

摘要

目的:探讨视网膜母细胞瘤易感基因（Rb）和微染色体维持蛋白2（MCM2）在前列腺癌发病机制中的作用及其临床意义。方法:应用免疫组化EliVisionTM plus二步法

检测49例前列腺癌（PCa）组织

20例良性前列腺增生（BPH）及10例正常前列腺组织（NP）中pRb蛋白与M CM 2的表达。结果:pRb在PCa

BPH与NP组织中的阳性表达率分别为44.90%

80%

90%

PCa中pRb的水平明显低于BPH（P<0.05）及NP（P<0.05）

且与PCa病理分级（P<0.05）和临床分期（P<0.05）呈负相关。M CM 2在PCa

BPH与NP组织中的阳性表达率分别为67.35%

25%和10%

PCa中M CM 2的水平明显高于BPH（P<0.05）及NP（P<0.05）

且与PCa病理分级（P<0.05）和临床分期（P<0.05）呈正相关。M CM 2表达与pRb表达呈负相关（rs=-0.596

P<0.01）。结论:Rb基因参与了前列腺癌的发生、发展过程

检测Rb基因和M CM 2有助于判定前列腺癌恶性程度及预后。

Abstract

Objective: To study the expression of retinoblastoma susceptibility gene(Rb) and minichromosome maintenance protein 2(MCM2) in primary prostate cancer(PCa) and its clinical significance.Methods: The expression of MCM2 protein and pRb were detected in 49 cases of PCa

20 cases of benign prostate hyperplasia(BPH)

10 cases of normal prostate tissues(NP) by EliVisionTM plus immunohistochemical staining.Results: The positive expression rate of pRb in PCa

BPH

NP were 44.90%

80% and 90% respectively.The expression level of pRb in PCa was significantly lower than that in BPH(P<0.05) and NP(P<0.05)

and was negatively correlated with pathological grades(P<0.05) and clinical stages(P<0.05) of PCa.The positive expression rate of MCM2 in PCa

BPH

NP were 67.35%

25% and 10% respectively

however

the expression level of MCM2 in PCa was significantly higher than that in BPH(P<0.05) and NP(P<0.05)

and was positively correlated with pathological grades(P<0.05) and clinical stages(P<0.05) of PCa.The expression level of MCM2 in PCa was negatively correlated with pRb(rs =-0.596

P <0.01).Conclusion: Rb might be involved in the occurrence and development of PCa.The determination of Rb and MCM2 can be an index for estimating the level of malignancy and prognosis of PCa.

关键词

前列腺癌微染色体维持蛋白2（MCM2）视网膜母细胞瘤易感基因（Rb）

Keywords

prostate cancerMinichromosome maintenance protein 2(MCM2)Retinoblastoma susceptibility gene(Rb)

references

Views

115

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

The expression of MTAP in prostate cancer and its effect on immune cells

miR-520a-5p induces docetaxel resistance in prostate cancer cells by regulating aerobic glycolysis

Causal relationship between thyroid dysfunction and prostate cancer： a two-sample Mendelian randomization study

Potential application of chymotrypsin-like proteasome activity as a biomarker for prostate cancer

A comparison of the diagnostic value of transrectal and transperineal prostate biopsies for prostate cancer

Related Author

Qin Zizhen

Liu Qingyuan

Wu Yuqi

Su Shuai

Zhang Jindong

Li Yue

Wang Delin

Xie Jianyun

Related Institution

Molecular Medicine and Tumor Research Center of Chongqing Medical University

Department of Urology,South China Hospital Affiliated to Shenzhen University

Department of Urology,the First Affiliated Hospital of Chongqing Medical University

Department of Urology，The People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine

The Second Clinical College of Guangzhou University of Chinese Medicine

⁰