Endurance of normal New Zealand Rabbits’ brain tissue after high intensity focused ultrasound ablation

BIAN Wei; et al

您当前的位置：

首页 >

文章列表页 >

Endurance of normal New Zealand Rabbits’ brain tissue after high intensity focused ultrasound ablation

更新时间：2024-01-17

- Endurance of normal New Zealand Rabbits’ brain tissue after high intensity focused ultrasound ablation
- Journal of Chongqing Medical University Issue 5, Pages: 641-644(2006)
- 作者机构：
  
  1. 重庆肿瘤医院神经外科
  2. 重庆医科大学附属第一医院神经外科
  3. 重庆医科大学医学超声工程研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC： R364
- Published：2006，
扫描看全文
[1]卞伟,支兴刚,王智彪,白晋,李发琪,谭启华,李崇雁.兔脑在高强度聚焦超声作用下的耐受性研究[J].重庆医科大学学报,2006(05):641-644+661.

BIAN Wei, et al. Endurance of normal New Zealand Rabbits’ brain tissue after high intensity focused ultrasound ablation. [J]. Journal of Chongqing Medical University (5):641-644(2006)
[1]卞伟,支兴刚,王智彪,白晋,李发琪,谭启华,李崇雁.兔脑在高强度聚焦超声作用下的耐受性研究[J].重庆医科大学学报,2006(05):641-644+661. DOI：

BIAN Wei, et al. Endurance of normal New Zealand Rabbits’ brain tissue after high intensity focused ultrasound ablation. [J]. Journal of Chongqing Medical University (5):641-644(2006) DOI：

摘要

目的:观察正常兔脑组织在不同剂量高强度聚焦超声（High intensity focused ultrasound

HIFU）作用后的反应和生存状态

探讨HIFU对脑部疾病治疗的可行性。方法:在总辐照时间不变的情况下

分组用不同的单次时间对24只新西兰兔脑组织进行定位损伤。观察实验兔的反应及生存状况

5周后处死取材

先用氯化三苯基四氮（triphenyl tetrazolium choloride

TTC）染色观察后

常规HE染色

光镜下观察组织学变化。结果:观察期内实验兔的生存状态在单次作用时间≥20s后明显变差

与作用次数无明显关系

组织学变化提示单次作用时间5￣10s效果为最佳。结论:HIFU能有效定位损伤深部脑组织

单次作用剂量适宜时是安全的

而与作用次数无关。

Abstract

Objective:The purpose of this study is to determine if HIFU is feasible for the treatment of brain diseases by observing New Zealand Rabbits’ reaction

living status and variation in microscope after different dosages of ablation.Methods:By using the same total time of HIFU exposure

we took different divided time to sonicate localized brain tissues of 24 New Zealand Rabbits for several times

to observe the rabbits’ reaction and living status.All animals were sacrificed after 5 weeks.Then we applied TTC stain to observe the gross changes and HE stain to observe histological changes in microscope.Results:During the observation period

the rabbits’ living status was apparently getting worse when the single exposure was ≥ 20 second(s).The times of exposure were not correlated with living status.According to our observation

the rabbits could tolerate the dose of HIFU exposure <5W×20s

but histological and statistic study indicated that the best single exposure time was 5~10s.Conclusion:HIFU could ablate deep localized brain tissue with little effect on the superficial tissue.The toleration to HIFU exposure for brain tissue is correlated with single dose of sonication

but independent from times of exposure.

关键词

高强度聚焦超声耐受性脑组织

Keywords

high intensity focused ultrasoundEnduranceBrain tissue

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

The study of bladder cancer cell line irradiated with high intensity focused ultrasound

Dosage and real time monitoring using two-dimensional ultrasound in extracorporeal damaging rabbit liver with high intensity focused ultrasound

Pathological regression at the focus in normal New Zealand Rabbits’ brain tissue after high intensity focused ultrasound ablation

Establishment of a two-dimensional electrophoresis technology on brain tissue protein of rat

Anesthesia management of the high intensity focused ultrasound therapy

Related Author

王智彪

伍烽

张唯力

杨光永

et al

LIU Chuan

王智彪

李发琪

Related Institution

Department of Urology, the Second College of Clinical Medicine , Chongqing Medical University

重庆医科大学超声工程研究所

Department of Biomedical Engineering,Institute of Ultrasound Engineering ,Chongqing Medical University

重庆医科大学检验系

⁰