A curative effect study of cefmetazole on the acute bacterial infection of respiratory system

PENG Fengying; et al

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A curative effect study of cefmetazole on the acute bacterial infection of respiratory system

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- A curative effect study of cefmetazole on the acute bacterial infection of respiratory system
- Journal of Chongqing Medical University Issue 2, Pages: 195-198(2007)
- 作者机构：
  
  1. 重庆医科大学附属第一医院传染科重庆市传染病寄生虫病学重点实验室
  2. 重庆医科大学附属第一医院传染科重庆市传染病寄生虫病学重点实验室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R56
- Published：2007，
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[1]彭凤英,卓超,黄文祥,李崇智.头孢美唑钠治疗呼吸系统急性细菌性感染疗效观察[J].重庆医科大学学报,2007(02):195-198.

PENG Fengying, et al. A curative effect study of cefmetazole on the acute bacterial infection of respiratory system. [J]. Journal of Chongqing Medical University (2):195-198(2007)
[1]彭凤英,卓超,黄文祥,李崇智.头孢美唑钠治疗呼吸系统急性细菌性感染疗效观察[J].重庆医科大学学报,2007(02):195-198. DOI：

PENG Fengying, et al. A curative effect study of cefmetazole on the acute bacterial infection of respiratory system. [J]. Journal of Chongqing Medical University (2):195-198(2007) DOI：

摘要

目的:评价国产注射用头孢美唑钠治疗中、重度呼吸系统细菌性感染的临床疗效和安全性。方法:采用双盲、随机、平行对照试验设计

以进口头孢美唑钠为对照药物。两组均为每次静脉滴注给药2.0g

q12h

疗程均为5～12天。结果:本次试验共入选病例数为48例

两组各为24例。可纳入临床疗效分析的病例数为46例

试验组24例

对照组22例。治疗结束时试验组和对照组临床有效率分别为75.0%和81.82%

两组细菌清除率分别为88.89%

81.25%

不良反应发生率分别为8.33%、16.67%。以上结果经统计学处理均无显著性差异。结论:国产头孢美唑钠注射剂治疗细菌性呼吸系统感染临床疗效确切

安全性好。

Abstract

Objective:To evaluate the curative effect and safety of domestic cefmetazole sodium for injection on moderate and severe bacterial infection of respiratory system.Methods:A clinical trial by randomized

double-blind

parallel control was conducted.The control drug was imported cefmetazole.Both groups were administered intravenously at a dose of 2 gram twice daily for 5 to 12 days.Results:A total of 48 patients were randomized into the treatment group and the control group

while 46 of them were enrolled in the statistical analysis of the clinical efficacy

with 24 patients in the treatment group and 22 in the control group.At the end of the treatment

the effective rate was 75.0% in the treatment group and 81.82% in the control one.The bacterial clearance rate and the drug-related adverse reaction rate were 88.89% and 8.33% in the treatment group

and 81.25% and 16.67% in the control one

respectively.There were no significant statistical differences between the two groups.Conclusion:Domestic cefmetazole sodium for injection was effective and safe in the treatment of bacterial infection of respiratory system.

关键词

头孢美唑随机双盲平行对照临床试验

Keywords

CefmetazoleRandomized double-blind parallel controlclinical trial

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