Study on prevention and therapeutic effects of simvastatin on osteoporosis in rats

MA Qingfen; et al

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Study on prevention and therapeutic effects of simvastatin on osteoporosis in rats

更新时间：2024-01-17

- Study on prevention and therapeutic effects of simvastatin on osteoporosis in rats
- Journal of Chongqing Medical University Issue 2, Pages: 150-153(2007)
- 作者机构：
  
  1. 重庆医科大学附属第一医院妇产科
  2. 重庆医科大学附属第一医院妇产科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R580
- Published：2007，
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[1]马庆芬,姚珍薇.辛伐他汀对去势大鼠骨质疏松防治作用的试验研究[J].重庆医科大学学报,2007(02):150-153.

MA Qingfen, et al. Study on prevention and therapeutic effects of simvastatin on osteoporosis in rats. [J]. Journal of Chongqing Medical University (2):150-153(2007)
[1]马庆芬,姚珍薇.辛伐他汀对去势大鼠骨质疏松防治作用的试验研究[J].重庆医科大学学报,2007(02):150-153. DOI：

MA Qingfen, et al. Study on prevention and therapeutic effects of simvastatin on osteoporosis in rats. [J]. Journal of Chongqing Medical University (2):150-153(2007) DOI：

摘要

目的:观察辛伐他汀对去势大鼠骨质疏松防治的作用。方法:40只雌性SD大鼠

随机平均分为4组

即假手术组、去势对照组、雌激素组（苯甲酸雌二醇0.1mg/kg

每三天皮下注射一次

连续用药至动物处死）、辛伐他汀组（辛伐他汀5mg/（kg.d）灌胃连用2周

停用5周

再连用2周

停药处死动物）。术后一个月开始药物干预。试验开始及处死动物后分别测定大鼠股骨的骨密度

放射免疫法测定IL-6、BGP的值

光镜下观察大鼠股骨病理学变化。结果:试验结束时

去势对照组大鼠骨密度BMD低于假手术组

雌激素组、辛伐他汀组的BMD高于去势对照组

均P<0.05。去势对照组的IL-6的值高于假手术组

治疗组IL-6的值低于去势对照组

而雌激素组IL-6的值低于辛伐他汀组

均P<0.05。去势对照组的BGP高于假手术组

而治疗组的BGP高于去势对照组

辛伐他汀组的BGP高于雌激素组

均P<0.05。治疗组与去势对照组相比骨组织病理学变化均有改善。结论:辛伐他汀能增加骨质疏松大鼠的骨密度

改善骨组织病理学变化

提高BGP的水平

降低IL-6的水平

有效的防治骨质疏松。

Abstract

Objective:To observe the prevention and therapeutic effects of simvastatin on the osteoporosis in rats.Methods:Forty SD female rats were randomly divided into four groups:sham operation group

OVX group

estrogen group and simvastatin group.One month after OVX operation

we began medicine intervention.Estrogen group was subcutaneously injected EB(0.1mg/kg)per triduum until being sacrificed.Simvastatin group was intragastrically administered simvastatin 5mg/(kg.d)for 2 weeks

then the administration was stopped for 5 weeks and then continued for 2 weeks until being sacrificed.After the intervention

we observed the change of rats’ BMD

bone histopathology and expressions of IL-6 and BGP.Results:The level of BMD in OVX group was lower than that in the sham group(P<0.05).The level of BMD raised in treated groups compared to the OVX group(P<0.05).The expression of IL-6 in OVX group raised compared to the sham group(P<0.05).The expression of IL-6 in all treated groups degraded compared to the OVX group(P<0.05)

especially in the estrogen group.The expression of BGP in OVX group raised compared to the sham group(P<0.05).The expression of BGP in all treated groups

especially the simvastatin group

significantly raised compared to the OVX group(P<0.05).The change of bone histopathology in treated groups was ameliorated compared to the OVX group.Conclusion:Simvastatin could effectively prevent and cure osteoporosis by elevating BMD

ameliorating the bone histopathology

raising the expression of BGP and degrading the expression of IL-6.

关键词

辛伐他汀骨质疏松

Keywords

simvastatinosteoporosis

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