Evaluation on cytotoxicity of propolis and calcium hydroxide

ZHANG Hongmei; et al

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Evaluation on cytotoxicity of propolis and calcium hydroxide

更新时间：2024-01-17

- Evaluation on cytotoxicity of propolis and calcium hydroxide
- Journal of Chongqing Medical University Issue 11, Pages: 1193-1195(2007)
- 作者机构：
  
  1. 重庆医科大学附属口腔医院预防科
  2. 重庆医科大学附属口腔医院预防科,重庆,400015
- 作者简介：
- 基金信息：
- DOI：
  CLC： R96
- Published：2007，
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[1]张红梅,林居红,蒋琳.蜂胶与氢氧化钙单独用药的细胞毒性研究[J].重庆医科大学学报,2007(11):1193-1195.

ZHANG Hongmei, et al. Evaluation on cytotoxicity of propolis and calcium hydroxide. [J]. Journal of Chongqing Medical University (11):1193-1195(2007)
[1]张红梅,林居红,蒋琳.蜂胶与氢氧化钙单独用药的细胞毒性研究[J].重庆医科大学学报,2007(11):1193-1195. DOI：

ZHANG Hongmei, et al. Evaluation on cytotoxicity of propolis and calcium hydroxide. [J]. Journal of Chongqing Medical University (11):1193-1195(2007) DOI：

摘要

目的:研究蜂胶与氢氧化钙（Ca（OH）2）对人牙龈成纤维细胞的细胞毒性作用。方法:采用四甲基偶氮唑盐（MTT）法分别评价蜂胶与Ca（OH）2溶液对人牙龈成纤维细胞相对增殖率的影响

用五级毒性分类法评级

并对结果进行统计分析。结果:0.1%～0.6%蜂胶与Ca（OH）2各稀释溶液毒性级均为1～2级

二者之间无显著性差异。结论:蜂胶与Ca（OH）2均对人牙龈成纤维细胞的毒性较小

是治疗口腔疾病的安全药物。

Abstract

Objective:To evaluate the cytotoxicity of propolis and calcium hydroxide for human gingival fibroblast.Methods:Human gingival fibroblast(HGF)was incubated in culture solution containing propolis or calcium hydroxide at different concentrations.The relative growth rates(RGR)were examined by method of MTT assay and cytotoxicity was classified by the five-class method.Then the results were statistically analysed.Results:The cytotoxicities of both 0.1% to 0.6% propolis and calcium hydroxide solutions at different concentration were all graded as first or second class.There was no statistical difference between them.Conclusion:Propolis and calcium hydroxide have weak cytotoxicity for HGF and they are all safe as local application for oral diseases.

关键词

蜂胶氢氧化钙细胞毒性人牙龈成纤维细胞

Keywords

PropolisCalcium hydroxidecytotoxicityHuman gingival fibroblast

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Related Author

ZHANG Hong-mei

et al

蒋琳

Lai Xiaofei

Xu Lei

Related Institution

Department of Prevention,the Affliliated Stomatology Hospital,Chongqing Medical University

Department of Laboratory，Ｔhe First Affiliated Hospital of Chongqing Medical University

Teaching and Research Section of Pathogenic Biology，Ministry of Education Key Laboratory of Molecular Biology on Infectious Diseases，Chongqing Medical University

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