Objective:To observe the positive rate of anti-myeloperoxidase(MPO) antibody in different kinds of primary and secondary glomerular diseases

to explore the clinical significance of anti-neutrophilic cytoplasmic autoantibody.Methods: The levels of serum anti-MPO antibody of 349 patients with kinds of primary or secondary renal glomerular diseases and 35 control subjects were measured by enzyme-linked immunosorbent assay.Results:Compared with the control group

the levels of serum anti-MPO antibody in patients with latent glomerulonephritis

hepatitis B virus associated glomerulonephritis(HBV-GN)

chronic glomerulonephritis

nephrotic syndrome or chronic renal failure had no significant difference(P>0.05).The levels of serum anti-MPO antibody in patients with lupus nephritis(LN)and purpuric glomerulonephritis had significantly increased(P<0.01).The level of plasma anti-MPO antibody of lupus nephritis and purpuric glomerulonephritis was the highest and much higher than that of normal control and patients with other glomerular diseases(P<0.05).The positive rate of anti-MPO antibody in patients with various glomerular diseases was 0%~23.81%.There was no positive plasma anti-MPO antibody in healthy controls or patients with latent glomerulonephritis

or hepatitis B virus associated glomerulonephritis.Conclusion:The incidence of anti-MPO antibody in various glomerular diseases was 5.73%.The level and positive rate of plasma anti-MPO antibody in patients with lupus nephritis was the highest among secondary glomerular diseases.As an important mark for reference

anti-MPO antibody could be used to clinically differentiate lupus nephritis and purpuric nephritis from latent glomerulonephritis and Hepatitis B virus associated glomerulonephritis.