Correlation between aluminum overload-induced brain neurodegeneration and monoamine oxidase B in mouse brain

WU Ke; et al

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Correlation between aluminum overload-induced brain neurodegeneration and monoamine oxidase B in mouse brain

更新时间：2024-01-17

- Correlation between aluminum overload-induced brain neurodegeneration and monoamine oxidase B in mouse brain
- Journal of Chongqing Medical University Issue 2, Pages: 125-128(2007)
- 作者机构：
  
  1. 重庆医科大学药学院药理教研室
  2. 重庆医科大学药学院药理教研室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R114
- Published：2007，
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[1]吴柯,周歧新.铝过负荷致小鼠脑神经元退变与脑单胺氧化酶B的关系[J].重庆医科大学学报,2007(02):125-128+133.

WU Ke, et al. Correlation between aluminum overload-induced brain neurodegeneration and monoamine oxidase B in mouse brain. [J]. Journal of Chongqing Medical University (2):125-128(2007)
[1]吴柯,周歧新.铝过负荷致小鼠脑神经元退变与脑单胺氧化酶B的关系[J].重庆医科大学学报,2007(02):125-128+133. DOI：

WU Ke, et al. Correlation between aluminum overload-induced brain neurodegeneration and monoamine oxidase B in mouse brain. [J]. Journal of Chongqing Medical University (2):125-128(2007) DOI：

摘要

目的:采用铝负荷致小鼠脑损伤模型

探讨铝致神经元退行性变与脑单胺氧化酶B代谢失衡的关系。方法:每鼠侧脑室内分别注射浓度为0.125%、0.25%、0.5%的AlCl3 3μl

连续给药5天

建立不同量铝过负荷致脑损伤小鼠模型。于给药后第10天、第20天和第30天测定小鼠学习记忆功能、海马病理形态学改变、单胺氧化酶B（Monoamine oxidase B

MAO-B）活性。结果:铝过负荷致小鼠脑内MAO-B活力显著升高和CA1区出现明显神经元丢失及核固缩;上述指标均呈剂量依赖性和时间依赖性改变。结论:铝过负荷致神经元退变可能与其干扰脑单胺氧化酶B代谢有关。

Abstract

Objective:To adopt the brain lesion model of mouse induced by overload aluminum to study the relationship between monoamine oxidase B disorder and neurodegeneration induced by overload aluminum(Al).Method:Aluminum overload models were established by injection of 3μl AlCl3 into lateral ventricle of miceeach day for 5d.The AlCl3 solutions injected in different modelswere with different concentrations and they were 0.125%

0.25%

0.5%.On d10

d20

and d30 after the final administration of AlCl3 solution

the learning and memory function of mice

pathomorphology of hippocampi

and MAO-B activity were determined.Results:Aluminum overload elevated MAO-B activity

caused karyopyknosis and loss of neurons in CA1 area of hippocampi

in dose-and time-dependent manners.Conclusion:The results indicate that neurodegeneration induced by Al toxicity may be related to the monoamine oxidase B homeostasis interfered by Al overload.

关键词

铝过负荷神经元退变MAO-B

Keywords

Aluminum overloadNeurodegenerationMonoamine oxidase B(MAO-B)

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Study of the relationship between aluminum overload-induced neurodegeneration and systems of oxidative stress and anti-oxidative stress in mice

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周歧新

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Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology,Chongqing Medical Vmversity

重庆医科大学重庆市生物化学与分子药理学重点实验室

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博士生导师

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