Protective effect of sivelestat sodium on ischemia reperfusion brain injury in rats

YANG Jiadan; et al

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Protective effect of sivelestat sodium on ischemia reperfusion brain injury in rats

更新时间：2024-01-17

- Protective effect of sivelestat sodium on ischemia reperfusion brain injury in rats
- Journal of Chongqing Medical University Issue 6, Pages: 578-580(2007)
- 作者机构：
  
  1. 重庆医科大学药理教研室
  2. 重庆医科大学药剂教研室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R743.3
- Published：2007，
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[1]杨佳丹,董志,欧阳净.西维来司钠对实验性大鼠脑缺血再灌注损伤的保护作用[J].重庆医科大学学报,2007(06):578-580.

YANG Jiadan, et al. Protective effect of sivelestat sodium on ischemia reperfusion brain injury in rats. [J]. Journal of Chongqing Medical University (6):578-580(2007)
[1]杨佳丹,董志,欧阳净.西维来司钠对实验性大鼠脑缺血再灌注损伤的保护作用[J].重庆医科大学学报,2007(06):578-580. DOI：

YANG Jiadan, et al. Protective effect of sivelestat sodium on ischemia reperfusion brain injury in rats. [J]. Journal of Chongqing Medical University (6):578-580(2007) DOI：

摘要

目的:研究西维来司钠对实验性大鼠脑缺血再灌注损伤的保护作用

并探讨其作用机制。方法:体外培养大鼠神经元

以缺氧加缺糖培养建立神经元“缺血”性损伤模型

观察西维来司钠对培养神经元“缺血”性损伤的保护作用。结果:西维来司钠（10-8

10-7及10-6mol/L）能明显增高模型细胞的活性;能显著降低模型细胞乳酸脱氢酶（LDH）漏出率;明显降低裂解液中MDA含量

提高SOD活性。结论:西维来司钠对大鼠脑神经元“缺血”损伤具有保护作用

其机制可能与其抗过氧化作用有关。

Abstract

Objective:To explore the protective effect of sivelestat sodium on cerebral ischemia reperfusion in rats and its mechanism.Methods:The neurons of neonate rat were cultured in vitro.The protective effects of sivelestat sodium on ischemia injury were observed by treating cells in glucose-free and oxygen-free medium.Results:Sivelestat sodium(10-8、10-7 and 10-6mol/L)increased the activity of neurons

reduced the leakage rate of LDH

increased the activity of SOD and reduced the content of MDA.Conclusion:sivelestat sodium protects the neurons against ischemia injury by suppressing the generation of lipid peroxide.

关键词

脑缺血再灌注损伤西维来司钠神经元细胞培养

Keywords

Cerebral ischemia reperfusion damagesivelestat sodiumneuroncell culture

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