A multicenter,randomized controlled clinical study on domestic doxycycline hydrolic chlorid intravenous in the treatment of bacterial infections

JIA Bei; et al

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A multicenter,randomized controlled clinical study on domestic doxycycline hydrolic chlorid intravenous in the treatment of bacterial infections

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- A multicenter,randomized controlled clinical study on domestic doxycycline hydrolic chlorid intravenous in the treatment of bacterial infections
- Journal of Chongqing Medical University Issue 9, Pages: 963-968(2007)
- 作者机构：
  
  1. 重庆市传染病寄生虫病重点实验室重庆医科大学附属第一医院感染科
  2. 重庆医科大学附属第二医院呼吸科
  3. 第三军医大学新桥医院泌尿外科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R515
- Published：2007，
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[1]贾蓓,卓超,黄文祥,李崇智,周向东,张唯力,吴国明,张艮甫.注射用盐酸多西环素随机对照治疗细菌性感染多中心临床研究[J].重庆医科大学学报,2007(09):963-968+973.

JIA Bei, et al. A multicenter,randomized controlled clinical study on domestic doxycycline hydrolic chlorid intravenous in the treatment of bacterial infections. [J]. Journal of Chongqing Medical University (9):963-968(2007)
[1]贾蓓,卓超,黄文祥,李崇智,周向东,张唯力,吴国明,张艮甫.注射用盐酸多西环素随机对照治疗细菌性感染多中心临床研究[J].重庆医科大学学报,2007(09):963-968+973. DOI：

JIA Bei, et al. A multicenter,randomized controlled clinical study on domestic doxycycline hydrolic chlorid intravenous in the treatment of bacterial infections. [J]. Journal of Chongqing Medical University (9):963-968(2007) DOI：

摘要

目的:评价注射用盐酸多西环素国产品治疗细菌性感染的疗效和安全性。方法:采用多中心随机双盲对照临床观察

以阿奇霉素为对照药

共246例患呼吸道或泌尿道感染的病人入组

纳入疗效分析240例

安全性分析246例。结果:注射用多西环素和阿奇霉素的痊愈率分别为63.33%（76/120）、75%（90/120）

有效率分别为94.17%（113/120）、96.67%（116/120）

细菌清除率分别为81.70%（67/82）和84.10%（69/82）

不良反应发生率分别为23.58%（29/123）和25.20%（31/123）。经统计学分析均无显著差异（P>0.05）。结论:国产注射用盐酸多西环素治疗呼吸道感染和泌尿道感染的疗效和安全性与注射用阿奇霉素相仿。

Abstract

Objective:To evaluate the clinical efficacy and safety of domestic doxycycline introvenous in the treatment of bacterial infections.Methods:A total of 246 patients with respiratory infections or urinary infections were enrolled into this multicenter

double-blinded

randomized controlled clinical study.Two hundred fourty patients received efficacy evaluation and 246 patients received evaluation of adverse events.Results:The cure and effective rates were 63.33% and 94.17% in doxycycline group

75% and 96.67% in arithromycine group;the bacterial eradication rate were 81.7% and 84.1%;the adverse events rate were 23.58% and 25.20%

respectively.There were no significant differences between the two groups(P>0.05).Conclusion:Domestic made doxycycline injection is as effective and safe as arithromycine injection for the treatment of bacterial infections.

关键词

多西环素阿奇霉素细菌感染随机对照临床试验

Keywords

DoxycyclineArithromycinBacterial infectionRandomized controlled clinical study

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