α-SMA,TGFβ1 in tissues on the surface of cavernosa of ventral penis with penile ventral curvature

LI Lang; et al

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α-SMA,TGFβ1 in tissues on the surface of cavernosa of ventral penis with penile ventral curvature

更新时间：2024-01-17

- α-SMA,TGFβ1 in tissues on the surface of cavernosa of ventral penis with penile ventral curvature
- Journal of Chongqing Medical University Issue 6, Pages: 635-637(2007)
- 作者机构：
  
  1. 重庆医科大学儿童医院泌尿外科
  2. 重庆医科大学儿童医院泌尿外科,重庆,400014
- 作者简介：
- 基金信息：
- DOI：
  CLC： R726.9
- Published：2007，
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[1]李浪,魏光辉,刘星,张德迎,张超.α-SMA、TGFβ1在尿道下裂阴茎下弯组织中的表达及意义[J].重庆医科大学学报,2007(06):635-637.

LI Lang, et al. α-SMA,TGFβ1 in tissues on the surface of cavernosa of ventral penis with penile ventral curvature. [J]. Journal of Chongqing Medical University (6):635-637(2007)
[1]李浪,魏光辉,刘星,张德迎,张超.α-SMA、TGFβ1在尿道下裂阴茎下弯组织中的表达及意义[J].重庆医科大学学报,2007(06):635-637. DOI：

LI Lang, et al. α-SMA,TGFβ1 in tissues on the surface of cavernosa of ventral penis with penile ventral curvature. [J]. Journal of Chongqing Medical University (6):635-637(2007) DOI：

摘要

目的:探讨尿道下裂阴茎下弯畸形阴茎海绵体腹侧表面组织病理学特点

认识尿道下裂阴茎下弯形成机制

为临床治疗方案提供一定的依据。方法:以尿道下裂伴阴茎下弯23例为研究对象

3例隐匿性阴茎手术病例为对照组和3例躯体瘢痕病例

应用免疫组织化学SABC检测组织中α-SMA、TGFβ1的阳性表达情况。结果:尿道下裂组和瘢痕组α-SMA、TGFβ1表达强度均较对照组明显升高

存在统计学差异（P<0.05）;尿道下裂轻度、中度及重度下弯三组之间无显著性差异。结论:尿道下裂并发阴茎下弯者

其阴茎海绵体腹侧表面及尿道板下组织为纤维索带

可能是阴茎下弯形成的病理学基础。

Abstract

Objective:To evaluate the pathological characteristics of tissues on the surface of cavernosa of ventral penis with ventral curvature and to investigate the etiology of congenital ventral curved hypospadias.Methods:α-smooth musle actin(α-SMA)

transforming growth factorβ1(TGFβ1) in tissue sections of 23cases of hypospadias with penile ventral curvature

3 concealed penis and 3 somatic scar were detected by immunohistochemical method of SABC.Result:The expressions of α-SMA

TGFβ1 in hypospadic ventral areas were markedly higher than those in normal and scar tissues(P<0.05).Conclusions:Rich fibrous tissues are present in the hypospadic specimens analysed

which possibly contributes to penile curvature of hypospadias.

关键词

尿道下裂阴茎下弯α-平滑肌动蛋白转化生长因子β1

Keywords

hypospadiasCurvatureα-smooth musle actin(α-SMA)Transforming growth factorβ1(TGFβ1)

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