Clinical and pathological features of keratoacanthoma

SHAN Kui; et al

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Clinical and pathological features of keratoacanthoma

更新时间：2024-01-17

- Clinical and pathological features of keratoacanthoma
- Journal of Chongqing Medical University Issue 4, Pages: 416-418(2007)
- 作者机构：
  
  1. 重庆医科大学附属第一医院皮肤科
  2. 重庆医科大学附属第一医院皮肤科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R739.5
- Published：2007，
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[1]单葵,李桂明.角化棘皮瘤的临床与病理分析[J].重庆医科大学学报,2007(04):416-418.

SHAN Kui, et al. Clinical and pathological features of keratoacanthoma. [J]. Journal of Chongqing Medical University (4):416-418(2007)
[1]单葵,李桂明.角化棘皮瘤的临床与病理分析[J].重庆医科大学学报,2007(04):416-418. DOI：

SHAN Kui, et al. Clinical and pathological features of keratoacanthoma. [J]. Journal of Chongqing Medical University (4):416-418(2007) DOI：

摘要

目的:探讨角化棘皮瘤的临床、病理学特征、恶性程度及预后。方法:收集18例角化棘皮瘤患者资料

观察和分析其临床和组织病理学特征

并通过免疫组化方法分析其p53、bcl-2及P-gp的表达。结果:角化棘皮瘤的典型皮损为边界清楚的半球状隆起

中央形成“火山口”样溃疡

其中充满角化物质;组织病理以表皮向真皮内凹陷呈“火山口”状

其中充满角化物质

两侧的上皮细胞形成“唇缘”包绕瘤体为特征;首选手术治疗、长期随访。18例角化棘皮瘤中p53阳性表达明显高于正常对照组（P<0.05）

bcl-2、P-gp阳性表达与正常对照组相比没有显著性差异（P>0.05）。结论:角化棘皮瘤为低恶性的皮肤肿瘤

有特殊的临床及组织病理特点

免疫组化有助于判断肿瘤的发病、恶性程度及预后。

Abstract

Objective:To study the clinical and pathological features

malignancy and prognosis of keratoacanthoma(KA).Methods: Eighteen patients with KA were collected

and their clinical features were analyzed with pathological aspects observed by immunohistochemical SP techniques.Results:The typical lesion of KA is a hemispheric

dome-shaped

skin-colored nodule in which there is a smooth crater filled with a central keratin plug.Histological examination showed a crater filled with eosinophilic keratin.A"lip"formed by invagination of epidermis surrounds the keratin-filled crater.Wide excision of the lesions is the first choice for the treatment of KA. The expression levels of p53 was higher than controls(P<0.05).No statistical significance were found on the expression of bcl-2 and P-gp.Conclusions:KA is a skin malignant tumor with it’s typical clinical and pathological features. The diagnosis

malignancy and prognosis of KA can be confirmed by immunohistochemical staining.

关键词

角化棘皮瘤临床分析病理特征p53Bcl-2P-gp

Keywords

Keratoacanthomaclinical analysisPathological featurep53Bcl-2P-gp

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