Influence of intestinal flora dysregulation induced by antibiotic on immunity and toll-like receptor 2,4 gene expression in mice

LIU Chonghai; et al

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Influence of intestinal flora dysregulation induced by antibiotic on immunity and toll-like receptor 2,4 gene expression in mice

更新时间：2024-01-17

- Influence of intestinal flora dysregulation induced by antibiotic on immunity and toll-like receptor 2,4 gene expression in mice
- Journal of Chongqing Medical University Issue 8, Pages: 839-842(2007)
- 作者机构：
  
  1. 重庆医科大学附属儿童医院免疫实验室
  2. 重庆医科大学附属儿童医院免疫实验室重庆400014川北医学院附属医院儿科
  3. ,四川,637000
- 作者简介：
- 基金信息：
- DOI：
  CLC： R392
- Published：2007，
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[1]刘崇海,杨锡强,刘恩梅,赵晓东,刘玮,王莉佳.抗生素诱导小鼠肠道菌群失调对免疫功能和Toll样受体2、4基因表达的影响[J].重庆医科大学学报,2007(08):839-842.

LIU Chonghai, et al. Influence of intestinal flora dysregulation induced by antibiotic on immunity and toll-like receptor 2,4 gene expression in mice. [J]. Journal of Chongqing Medical University (8):839-842(2007)
[1]刘崇海,杨锡强,刘恩梅,赵晓东,刘玮,王莉佳.抗生素诱导小鼠肠道菌群失调对免疫功能和Toll样受体2、4基因表达的影响[J].重庆医科大学学报,2007(08):839-842. DOI：

LIU Chonghai, et al. Influence of intestinal flora dysregulation induced by antibiotic on immunity and toll-like receptor 2,4 gene expression in mice. [J]. Journal of Chongqing Medical University (8):839-842(2007) DOI：

摘要

目的:探讨抗生素诱导小鼠肠道菌群失调后对机体免疫功能和Toll样受体2、4的影响。方法:60只BALB/c小鼠分为2组:抗生素组和对照组

抗生素组连续7天口服头孢哌酮

7天后经口给予白色念珠菌。结果:抗生素组小鼠肠道内肠杆菌、肠球菌、双歧杆菌、乳酸杆菌较对照组减少

白色念珠菌增加;脾指数、PHA诱导的淋巴细胞转化率、迟发型变态反应、抗体生成细胞数和脾脏的TLR2和TLR4基因表达水平均低于对照组。结论:抗生素诱导肠道菌群失调后小鼠免疫功能和TLR2、TLR4 mRNA表达均降低。

Abstract

Objective:To study the effects of intestinal flora dysregulation induced by antibiotic on immune function and toll-like receptor(TLR)2

4.Methods:Sixty BALB/c mice were divided into two groups:antibiotic and control group.The mice in antibiotic group were treated with cefoperazone orally for consecutive 7 days.After 7 days

mice were inoculated with Candida albicans.Results:The quantity of Enterobacteriaceae

Enterococcus

Bifidobacterium and Lactobacillus in antibiotic therapy group was significantly lower than that in the control group.The quantity of Candida albicans increased in the antibiotic therapy group.Spleen index

lymphocytic transformation rate induced by PHA

delayed-type hypersensitivity and the number of antibody secreting cells

the gene expression of TLR2 and TLR4 mRNA in spleen were lower than those in the control group.Conclusions:The intestinal flora dysregulation induced by antibiotic may decrease the immune function and toll-like receptor 2

4 gene expression in mice.

关键词

抗生素肠道菌群免疫功能Toll样受体

Keywords

Antibioticintestinal floraImmunity functionToll-like receptor

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