Expression and significance of Y14 and Upf1 in human breast carcinoma cells and breast epithelial cell

KONG Lingquan; et al

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Expression and significance of Y14 and Upf1 in human breast carcinoma cells and breast epithelial cell

更新时间：2024-01-17

- Expression and significance of Y14 and Upf1 in human breast carcinoma cells and breast epithelial cell
- Journal of Chongqing Medical University Issue 10, Pages: 1013-1015(2007)
- 作者机构：
  
  1. 重庆医科大学附属第一医院普外科
  2. 重庆医科大学附属第一医院普外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.9
- Published：2007，
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[1]孔令泉,涂刚,任国胜.Y14和Upf1在人乳腺癌细胞与乳腺细胞中的表达及意义[J].重庆医科大学学报,2007(10):1013-1015+1069.

KONG Lingquan, et al. Expression and significance of Y14 and Upf1 in human breast carcinoma cells and breast epithelial cell. [J]. Journal of Chongqing Medical University (10):1013-1015(2007)
[1]孔令泉,涂刚,任国胜.Y14和Upf1在人乳腺癌细胞与乳腺细胞中的表达及意义[J].重庆医科大学学报,2007(10):1013-1015+1069. DOI：

KONG Lingquan, et al. Expression and significance of Y14 and Upf1 in human breast carcinoma cells and breast epithelial cell. [J]. Journal of Chongqing Medical University (10):1013-1015(2007) DOI：

摘要

目的:研究Y14和Upf1在人乳腺癌细胞株与人乳腺细胞株中的表达及意义。方法:应用Westernblotting、RT-PCR等方法测定Y14和Upf1在人乳腺癌细胞株MCF-7、ZR-75-30、T47D、MDA-MB-435s、MDA-MB-453、MDA-MB-231与乳腺细胞株HBL-100中的表达情况。结果:Y14和Upf1在乳腺癌细胞株与乳腺细胞株中的表达水平有明显差异

6株乳腺癌细胞中的Y14和Upf1表达明显高于乳腺细胞株（P<0.05）。结论:NMD在乳腺癌细胞株中的作用明显强于乳腺细胞株。

Abstract

Objective:To study the expression and significance of Y14 and Upf1 in human breast cancer cells and breast epithelial cell. Methods:Western blotting and RT-PCR were applied to detect the expression of Y14 and Upf1 in human breast cancer cells(MCF-7

ZR-75-30

T47D

MDA-MB-435s

MDA-MB-453

MDA-MB-231)and breast epithelial cell(HBL-100). Results:Y14 and Upf1 levels of the breast cancer cells were obviously higher than that of breast cell(P<0.05). Conclusion: NMD activity increased obviously in the breast cancer cells.

关键词

NMDY14Upf1人乳腺癌细胞人乳腺细胞Western印记

Keywords

NMDY14Upf1Human breast cancer cellsBreast epithelial cellWestern blotting

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