The significance of detecting interferon-γ,adenosine deaminase and neopterin in the diagnosis of tuberculous pleural effusion

WANG Xian-tao; et al

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The significance of detecting interferon-γ,adenosine deaminase and neopterin in the diagnosis of tuberculous pleural effusion

更新时间：2024-01-17

- The significance of detecting interferon-γ,adenosine deaminase and neopterin in the diagnosis of tuberculous pleural effusion
- Journal of Chongqing Medical University Issue 8, Pages: 987-989(2008)
- 作者机构：
  
  重庆医科大学医学检验系检验仪器学教研室临床检验诊断学省部共建教育部重点实验室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R521.7
- Published：2008，
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[1]汪先桃,曾照芳.γ-干扰素、腺苷脱氨酶和新喋呤对结核性胸膜炎的诊断价值[J].重庆医科大学学报,2008(08):987-989.

WANG Xian-tao, et al. The significance of detecting interferon-γ,adenosine deaminase and neopterin in the diagnosis of tuberculous pleural effusion. [J]. Journal of Chongqing Medical University (8):987-989(2008)
[1]汪先桃,曾照芳.γ-干扰素、腺苷脱氨酶和新喋呤对结核性胸膜炎的诊断价值[J].重庆医科大学学报,2008(08):987-989. DOI：

WANG Xian-tao, et al. The significance of detecting interferon-γ,adenosine deaminase and neopterin in the diagnosis of tuberculous pleural effusion. [J]. Journal of Chongqing Medical University (8):987-989(2008) DOI：

摘要

目的:研究胸水中γ-干扰素（Interferon-γ

IFN-γ）、腺苷脱氨酶（Adenosine deaminase

ADA）活性和新喋呤（Neopterin

Npt）水平对结核性胸膜炎的诊断价值。方法:分别用酶联免疫吸附试验（ELISA）和偶联速率法检测43例结核性和38例恶性胸膜炎患者胸水中γ-干扰素、腺苷脱氨酶活性和新喋呤水平

并绘制受试者工作特征曲线（Receiver operating characteristic curve

ROC曲线）评价3项指标检测结核性胸膜炎的敏感性和特异性。结果:结核性胸膜炎组胸水中γ-干扰素、腺苷脱氨酶活性和新喋呤水平均显著高于非结核性胸膜炎组（P<0.05）。结论:胸水中γ-干扰素、腺苷脱氨酶活性和新喋呤水平测定有助于结核性胸膜炎的诊断。

Abstract

Objective:To evaluate the significance of determination of the activity of adenosine deaminase(ADA)

and the level of interferon(IFN-γ) and neopterin(Npt) in the diagnosis of tuberculous pleuritis.Methods:Enzyme-linked immunosorbent assay(ELISA) and couple velocity assay were used to detect the activity of ADA

and the level of IFN-γ and neopterin in 43 patients with tuberculous pleuritis and 38 patients with pleural effusion associated with malignant tumor or other causes and the receiver operating characteristic(ROC) curves were also protracted.Results:The activity of ADA

and the level of IFN-γ and neopterin(P<0.05) were significantly higher in the tuberculous effusion than the fluid associated with other causes.Conclusion:Detection of IFN-γ

ADA and Npt of pleural fluid may be helpful in the diagnosis of tuberculous pleuritis.

关键词

结核性胸膜炎γ-干扰素腺苷脱氨酶新喋呤

Keywords

Tuberculous pleuritisInterferon-γAdenosine deaminaseNeopterin

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