Elementary investigaion of curative effects by DUXIL on cerebral dysfunction associated with disturbance of cerebral microcirculation

TAO Aimin; et al

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Elementary investigaion of curative effects by DUXIL on cerebral dysfunction associated with disturbance of cerebral microcirculation

更新时间：2024-01-17

- Elementary investigaion of curative effects by DUXIL on cerebral dysfunction associated with disturbance of cerebral microcirculation
- Journal of Chongqing Medical University Issue 9, Pages: 984-987(2007)
- 作者机构：
  
  1. 重庆市巫山县人民医院内科
  2. 重庆医科大学附属第一医院神内科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R749.1
- Published：2007，
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[1]陶爱民,杨军,杨琴,董为伟.都可喜治疗脑微循环障碍所致脑功能失调的初步探讨[J].重庆医科大学学报,2007(09):984-987.

TAO Aimin, et al. Elementary investigaion of curative effects by DUXIL on cerebral dysfunction associated with disturbance of cerebral microcirculation. [J]. Journal of Chongqing Medical University (9):984-987(2007)
[1]陶爱民,杨军,杨琴,董为伟.都可喜治疗脑微循环障碍所致脑功能失调的初步探讨[J].重庆医科大学学报,2007(09):984-987. DOI：

TAO Aimin, et al. Elementary investigaion of curative effects by DUXIL on cerebral dysfunction associated with disturbance of cerebral microcirculation. [J]. Journal of Chongqing Medical University (9):984-987(2007) DOI：

摘要

目的:观察都可喜（DUXIL）在人血液中红细胞形态及数目发生改变

致脑微循环障碍

随即导致脑功能失调

而引起脑缺血、缺氧的症状时的治疗作用及机制。方法:40例具有脑缺血、缺氧症状群的患者

随机分为两组

分别服用都可喜和尼莫地平共服15天

互为对照;分别于治疗前

治疗后做①查静脉血血常规;②脑循环功能（CVA）检测;③二组中各随机抽取2例患者做SPECT。结果:治疗前血常规红细胞各参数都有不同程度的增高

并伴有CVA各项指数的改变

SPECT的定性分析显示均有不同程度的低灌注区;治疗后

应用都可喜组红细胞各项参数均有所下调

并伴随着CVA各项指数的改善

以及SPECT的灌注缺损显著改善

临床症状随之减轻或消失

而尼莫地平组上述各项指标改善不明显

临床症状亦改善不明显。结论:都可喜能够干预红细胞

使之具有良好的红细胞变形能力（ED）

使脑微循环得到有效灌注

从而纠正脑缺血、缺氧症状。

Abstract

Objective:To observe DUXIL’s curative effects and mechanisms for cerebral ischemia and anoxia secondary to the alteration of altering the number and configuration of human erythrocyte

which results in cerebral microcirculatory disturbance and dysunction of cerebrum.Methods:The patients were divided into two groups randomly and each group had 20 patients who had the prodrome of cerebral ischemia and anoxia.One group took DUXIL and the other NIMODIPINE for 15 days for comparison.Blood test and CVA were performed separately before and after the treatment.Twenty patients were chosed randomly from each group for SPECT.Results:There are varging degrees increases of parameters of erythrocyte acompanyed by alteration of parameters of CVA before treatment and SPECT qualitative analysis shows areas of low perfusion with differents severities.The number and configuration of erythrocyte was changed in group taken DUXIL.The parameters of CVA had been improved and the defect of encephalic perfusion also amended.The clinical symptoms were alleviated or disappeared.But no improvement were obtained in the other group.Conclusion:DUXIL can improve symptoms of cerebral ischemia and anoxia by affecting erythrocyte to make it have more favourable erythrocyte deformability(ED)

which can contribute to effective perfusion of cerebral microcirculation.

关键词

脑微循环红细胞红细胞变行能力脑缺血、缺氧都可喜

Keywords

Cerebral microcirculationErythrocyteErythrocyte deformabilityCerebral ischemia and anoxiaDUXIL

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