The association of a CA repeat polymorphism in ERβ gene with unknown aetiology hypomenorrhea

LE Aiwen; et al

您当前的位置：

首页 >

文章列表页 >

The association of a CA repeat polymorphism in ERβ gene with unknown aetiology hypomenorrhea

更新时间：2024-01-17

- The association of a CA repeat polymorphism in ERβ gene with unknown aetiology hypomenorrhea
- Journal of Chongqing Medical University Issue 10, Pages: 1045-1048(2007)
- 作者机构：
  
  1. 重庆医科大学附属第一医院妇产科
  2. 首都医科大学附属复兴医院宫腔镜中心
- 作者简介：
- 基金信息：
- DOI：
  CLC： R711.5
- Published：2007，
扫描看全文
[1]乐爱文,袁瑞,夏恩兰,耿力,周晓曦,姚珍薇.雌激素受体β基因CA重复序列多态性与原因不明月经过少的关系[J].重庆医科大学学报,2007(10):1045-1048.

LE Aiwen, et al. The association of a CA repeat polymorphism in ERβ gene with unknown aetiology hypomenorrhea. [J]. Journal of Chongqing Medical University (10):1045-1048(2007)
[1]乐爱文,袁瑞,夏恩兰,耿力,周晓曦,姚珍薇.雌激素受体β基因CA重复序列多态性与原因不明月经过少的关系[J].重庆医科大学学报,2007(10):1045-1048. DOI：

LE Aiwen, et al. The association of a CA repeat polymorphism in ERβ gene with unknown aetiology hypomenorrhea. [J]. Journal of Chongqing Medical University (10):1045-1048(2007) DOI：

摘要

目的:研究雌激素受体β（Estrogen receptor β

ERβ）基因CA重复序列多态性与原因不明月经过少关系。方法:选择西南地区的100名月经正常人作为正常对照组

100名原因不明月经过少患者作为病例组。同时对人ERβ基因5号内含子的高变区CA重复序列进行纯化、克隆和序列分析

阐明该CA重复序列多态性在实验组与对照组当中的分布情况及与原因不明月经过少的关系。结果:共分离出9种等位基因

其（CA）n重复数目为16～24。正常组和病例组的等位基因的分布频率差异无显著性（χ2=7.155

P=0.520）。以重复次数n≤20作为SS型

n>20为LL型。SS基因型频率实验组为66%

对照组为51%

OR值:1.865倍（95%CI:1.055～3.298）。再比较两组病人SS型和LL等位基因型的分布频率

差异有显著性（χ2=4.634

P=0.031）。结论:ERβ基因CA重复序列多态性与原因不明月经过少有关

SS型等位基因型可能是原因不明月经过少的危险因素。

Abstract

Objective:To investigate the association of a (CA)n dinucleotide repeat polymorphism of ERβ with unknown aetiology hypomenorrhea. Methods:We choosed 100 eumenorrhea women as control group and another 100 hypomenorrhea patients as case group from Southwestern China. At the same time

we bring depuration

clone and sequence analysis to CA repeat polymorphism in 5 intron region of estrogen receptor β to illuminate its repeated sequence polymorphism distributing between control and case group and its relationship with unknown aetieological hypomenorrhea. Results:We got 9 alleles and the repeated number of (CA) n was 16～24. There was not difference between distributing frequencies of CA repeat polymorphism in control and case groups(χ2=7.155

P=0.520). SS genotype was defined as repeat number n≤20

LL for n>20. Case group SS genotype rate was 66%

control group 51%

OR=1.865(95%CI:1.055～3.298).The SS and LL allele genotypes frequency was compared in two groups and the difference was significant(χ2=4.634

P=0.031). Conclusion:ERβ gene CA repeat polymorphism is related to unknown aetiological hypomenorrhea. SS allele genotype may be the risk factor of unknown aetiological hypomenorrhea.

关键词

月经过少雌激素受体二核苷酸（CA）重复序列等位基因

Keywords

Hypomenorrheaestrogen receptor(CA) Dinucleotide repeat sequenceAllele

references

Views

163

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

The association of a TA repeat polymorphism in ERa gene with unknown aetiology hypomenorrhea

Effect of different dosages of estrogen on ovarian function and ESR1 expression after hysteroscopic adhesiolysis

CORRELATION OF ESTROGEN RECEPTOR CONTENT AND MORPHOMETRIC ULTRA-STRUCTURE OF BREAST CANCER

The observation of androgen receptor and estrogen receptor in hepatocellular carcinomas with immunoelectron - microscopy

Expressions of proliferating cell nuclearantigen, estrogen receptor and epidermal growth factor receptor in tumors of the gallbladder

Related Author

et al

YUAN Rui

Yuan Rui

Zhou Qin

Li Qiong

Zhang Zhenhuan

et al

汪康莹

Related Institution

重庆医科大学附属第一医院妇产科

Department of Obstetrics and Gynecology,The First Affiliated Hospital of Chongqing Medical University

重庆医科大学电镜室

Department of Surgery, College of Clinical Medicine .Chongqing Medical University

重庆医科大学基础医学院生物教研室

⁰