Effects of Shengmai injection on cytokines in serum of press-overload rats

ZHANG Xing-ping; et al

您当前的位置：

首页 >

文章列表页 >

Effects of Shengmai injection on cytokines in serum of press-overload rats

更新时间：2024-01-17

- Effects of Shengmai injection on cytokines in serum of press-overload rats
- Journal of Chongqing Medical University Issue 2, Pages: 203-206(2008)
- 作者机构：
  
  1. 重庆医科大学附属第二医院老年病科
  2. 重庆医科大学附属第二医院老年病科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：
  CLC： R285.5
- Published：2008，
扫描看全文
[1]张兴平,陈庆伟.生脉注射液对压力超负荷性大鼠血清细胞因子的影响[J].重庆医科大学学报,2008(02):203-206+249.

ZHANG Xing-ping, et al. Effects of Shengmai injection on cytokines in serum of press-overload rats. [J]. Journal of Chongqing Medical University (2):203-206(2008)
[1]张兴平,陈庆伟.生脉注射液对压力超负荷性大鼠血清细胞因子的影响[J].重庆医科大学学报,2008(02):203-206+249. DOI：

ZHANG Xing-ping, et al. Effects of Shengmai injection on cytokines in serum of press-overload rats. [J]. Journal of Chongqing Medical University (2):203-206(2008) DOI：

摘要

目的:研究压力超负荷性大鼠发生慢性心力衰竭（Chronic heart failure

CHF）时血清细胞因子的变化以及生脉注射液对其的影响

从免疫学角度探讨生脉注射液治疗CHF的作用机制。方法:雄性Wistar大鼠70只随机分为假手术组20只和模型组50只

分别行假腹主动脉缩窄术和腹主动脉缩窄术

8周后从每组选取10只进行血液动力学参数测定

若测定结果显示CHF大鼠模型建立成功

则将模型组余下大鼠随机分为对照组和生脉组。假手术组和对照组予以生理盐水治疗

生脉组予以生脉注射液治疗

4周后测定血液动力学参数和血清肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）和白细胞介素-10（IL-10）浓度。结果:对照组大鼠血清各细胞因子浓度均高于假手术组（P<0.01）

生脉组大鼠血清各细胞因子浓度均低于对照组（P<0.01）。结论:CHF时血清各细胞因子浓度异常升高

生脉注射液对此有明显的抑制作用。

Abstract

Objectives:To study the change of cytokines in serum of press-overload rats with chronic heart failure(CHF) and the effect of Shengmai injection on cytokines

to uncover the working mechanism of Shengmai injection in treatment of CHF from the standpoint of immunity.Methods:A total of 70 male Wistar rats were divided randomly into sham-operation group(20 rats) and model group(50 rats)

and sham-abdominal aortic stenosis operation and abdominal aortic stenosis operation were given respectively.After 8 weeks

10 rats of each group were randomly chosen to detect hemodynamics parameter.If the results showed the construction of the CHF model was successful

the rest rats of model group were divided randomly into control group and ShengMai group.The rats of sham-operation group and control group were given saline celiac injection

and the rats of ShengMai group were given ShengMai Injection celiac injection.After 4 weeks

hemodynamics parameter and serum concentrations of tumor necrosis factor-α(TNF-α)

interleukin-1β(IL-1β)

interleukin-6(IL-6) and interleukin-10(IL-10) were detected.Results:The serum concentrations of cytokines in control group were higher than those of sham-operation group(P<0.01)

and the concentrations of ShengMai group were lower than those of control group(P<0.01).Conclusions:The serum concentrations of cytokines increase abnormally in CHF

and ShengMai Injection could inhibit the change obviously.

关键词

生脉注射液慢性心力衰竭细胞因子

Keywords

Shengmai injectionchronic heart failurecytokine

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of α-lipoic acid on improving cardiac function of rats with chronic heart failure

Immunological mechanism of the cellular mediated xenograft rejection in the rat free fetal bowel to mouse transplantation

Experimental model of chronic heart failure resulting from pressure overload in juvenile rats and its pathophysiological changes

Acute lung injury induced by endotoxic shock and imbalance of Th1/Th2 type of cytokines

Evaluation of right ventricular function in patients with chronic heart failure by analyzing tricuspid annular motion

Related Author

Ding Juan

Luo Xiang

Zhang Siliang

Liu Dichuan

Wu Jian

杜成友

et al

ZHOU Hongwei

Related Institution

Department of Cardiology,the Second Affiliated Hospital,Chongqing Medical University

重庆医科大学临床学院普通外科

Department of General Surgery,the Second College of Clinical Medicine,Chongqing Medical University

⁰