Objective:To explore the relationship between the pathological classification and clinical manifestations of renal glomerular disease in children. Methods:Pathological diagnosis and laboratory routine examinations of total 377 patients with renal disease during Feb

1999 to Feb

2006 were reviewed and compared. Results:(1)There were 250 male and 127 female among 377 patients who received renal biopsy

and the ratio of male to female was 1.97. Among these patients

217(57.6%) cases of primary glomerular disease

158(41.9%) cases of secondary glomerular disease

1(0.25%) case of heritage glomerular diseases and 1 case of renal vascular disease were found

respectively. (2)The most common clinical diagnosis and pathological category in primary glomerulary disease were nephritic syndrome and mesangial proliferative glomerulonephritis(MsPGN)

respectively

and that in secondary glomerulary disease were Henoch-Schonlein purpura nephritis and MsPGN

respectively. The mean age in group of secondary glomerulary disease[(10.36±2.83)years] was older than that in group of primary glomerulary disease[(9.72±3.07)years]

(P<0.05). The incidence of IgA deposition within renal tissue and the incidence of focal segmental glomerulosclerosis(FSGS) and or tubulopathy other than the first pathological diagnosis in secondary glomerulary disease(84.2%

36.1%

respectively) were higher than those in primary glomerulary disease(54.4%

22.6%

respectively)

(P<0.01

respectively). Conclusions:(1)Primary glomerulary disease is still common glomerulary disease in children

and secondary glomerulary disease develops gradually with the increasement of age. MsPGN is the most common pathological category in children glomerulary disease. (2)In secondary glomerulary disease

the higher incidence of FSGS and or tubulopathy are possibly due to the higher incidence of IgA deposition within renal tissue.