Objective:To study the clinical value of measurement of serum

urine β

2

-microglobulin（β

2

-M）) and urine albium in patients with hyperthyroidism. Methods:The levels of serum β

2

-M

thyroid hormone（including T3、T4）

Cre

Urea and urine β

2

-M

and albium of 50 healthy volunteers（as control group） and 190 patients with hyperthyroidism were measured by radioimmunassay（RIA）.And the results were compared and analyzed. Results:Levels of serum β

2

-microglobulin and urine β

2

-microglobulin

and albium in the patients with hyperthyroidism（including the preliminary diagnosis group and unrelieved group） were significantly higher than those in control group and cured hyperthyroidism group（P

<

0.01）;those were significantly higher in unrelieved group than those in preliminary diagnosis group with hyperthyroidism（P

<

0.01）

and there was no significant difference between the control group and cured hyperthyroidism group in serum β

2

-M and urine β

2

-M

and albium（P

>

0.05）.There was favourable correlation between the serum β

2

-microglobulin and serum T3（the correlative coefficient was 0.91）.Conclusion:It is of great clinical significance to measure serum and urine β

2

-microglobulin combinding urine albium for concluding the degree of hyperthyroidism

as well as the location and degree of the damages of kedney.