Expression study of pleiotrophin and midkine in endometrium of endometriosis

YANG Lei; et al

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Expression study of pleiotrophin and midkine in endometrium of endometriosis

更新时间：2024-01-17

- Expression study of pleiotrophin and midkine in endometrium of endometriosis
- Journal of Chongqing Medical University Issue 4, Pages: 478-480(2008)
- 作者机构：
  
  1. 重庆医科大学附属第一医院妇产科
  2. 重庆医科大学附属第一医院妇产科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R711.71
- Published：2008，
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[1]杨蕾,赵纯全,令狐华.子宫内膜异位症在位内膜多效营养因子和中期因子的表达研究[J].重庆医科大学学报,2008(04):478-480.

YANG Lei, et al. Expression study of pleiotrophin and midkine in endometrium of endometriosis. [J]. Journal of Chongqing Medical University (4):478-480(2008)
[1]杨蕾,赵纯全,令狐华.子宫内膜异位症在位内膜多效营养因子和中期因子的表达研究[J].重庆医科大学学报,2008(04):478-480. DOI：

YANG Lei, et al. Expression study of pleiotrophin and midkine in endometrium of endometriosis. [J]. Journal of Chongqing Medical University (4):478-480(2008) DOI：

摘要

目的:探讨多效营养因子（Pleiotrophin

PTN）和中期因子（Midkine

MK）蛋白在子宫内膜异位症（Endometriosis

EMs）患者在位内膜组织中的表达变化及临床意义。方法:应用免疫组化链霉菌抗生物素蛋白-过氧化物酶连接（SP）法

检测30例EMs患者（研究组）的在位内膜组织及29例子宫肌瘤患者（对照组）的内膜组织中PTN和MK蛋白的表达。结果:PTN蛋白主要在子宫内膜腺上皮细胞浆和细胞膜中表达

而MK蛋白阳性表达也主要定位于子宫内膜腺上皮细胞的细胞浆

部分标本细胞核也有阳性表达。EMs组中PTN和MK蛋白表达均较对照组显著升高（P均<0.001）。结论:PTN和MK蛋白在EMs患者的在位内膜过度表达

导致其血管生成能力增强。EMs在位内膜中PTN和MK蛋白的表达变化可能与EMs的发生发展有关。

Abstract

Objective:To study the expression of Pleiotrophin and Midkine protein in endometrium of endometriosis and its clinical significance.Methods:Expressions of Pleiotrophin and Midkine protein were examined by immunohistochemical staining method in 30 endometrial samples of endometriosis(study group) and 29 endometrium of uterine fibroid(control group).Result:Pleiotrophin protein mainly expressed in the membrane and plasma of glandular epithelium of endometrium.Midkine protein mainly expressed in the plasma of grandular epithelium of endometrium and expressed in nuclei in some samples.The expression of Pleiotrophin and Midkine protein in endometriosis was significantly higher than that in the control group(P<0.001).Conclusions:over-expression of PTN and MK protein in endometrium of endometriosis correlated to endometriotic cell angiogenesis.The change of PTN and MK expression in endometrium of endometriosis may relate to the pathogenesis of endometriosis.

关键词

多效营养因子中期因子子宫内膜异位症新生血管

Keywords

PleiotrophinMidkineendometriosisNew blood vessels

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Department of Pathology,College of Basic Medical Science,Chongqing Medical University

重庆医科大学基础医学院病理学教研室

Department of Obstetrics and Gynecology,College of Clinical Medicine,Chongqing Medical University

重庆医科大学临床学院妇产科

Department of Chongqing Health Center for Women and Children

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