Pharmacokinetics of sinomenine in rabbits

ZHANG Si-han; et al

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Pharmacokinetics of sinomenine in rabbits

更新时间：2024-01-17

- Pharmacokinetics of sinomenine in rabbits
- Journal of Chongqing Medical University Issue 7, Pages: 868-870(2008)
- 作者机构：
  
  重庆医科大学附属第一医院临床药理研究室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R285
- Published：2008，
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[1]张斯汉,周远大,何海霞.青藤碱在家兔体内的药代动力学研究[J].重庆医科大学学报,2008(07):868-870.

ZHANG Si-han, et al. Pharmacokinetics of sinomenine in rabbits. [J]. Journal of Chongqing Medical University (7):868-870(2008)
[1]张斯汉,周远大,何海霞.青藤碱在家兔体内的药代动力学研究[J].重庆医科大学学报,2008(07):868-870. DOI：

ZHANG Si-han, et al. Pharmacokinetics of sinomenine in rabbits. [J]. Journal of Chongqing Medical University (7):868-870(2008) DOI：

摘要

目的:建立高效液相色谱法测定青藤（Sinomenine）碱在家兔体内的血药浓度并研究其药动学。方法:6只家兔分别给予青藤碱45mg/kg灌胃

于给药后0.25h、0.5h、1.0h、1.5h、2.0h、3.0h、4.0h、6.0h、8.0h、10.0h、12.0h分别取血2ml

采用高效液相色谱法检测血药浓度

3P97软件处理数据并进行药代动力学研究。结果:T1/（2Ka）为（0.31±0.26）h

T1/（2Ke）为（3.15±0.82）h

Tmax为（1.05±0.53）h

Cmax为（15.09±4.15）μg/ml

AUC0→∞为（84.27±13.02）（μg·h）/L

AUC0→T为（78.29±13.46）（μg·h）/L。结论:家兔灌服青藤碱后药物吸收和消除快

达峰时间短

血药浓度高。

Abstract

Objective:To establish a HPLC method for measurement of serum concentration of sinomemine in rabbits and explore it’s pharmacokinetics. Methods:6 rabbits were intragastricly administrated sinomenine with the dosage of 45mg/kg

2 ml blood were collected at 0.25h、0.5h、1.0h、1.5h、2.0h、3.0h、4.0h、6.0h、8.0h、10.0h and 12.0h after oral administration.concentrations of drug were determined by HPLC

datas were calculated with 3P97 software and pharmacokinetics was explored. Results:T1/2(Ka) was(0.31±0.26)h

T1/2(Ke) was(3.15±0.82)h

Tmax was(1.05±0.53)h

Cmax was(15.09±4.15)μg/ml

AUC0→∞ was(84.27±13.02)(μg·h)/L

AUC0→T was(78.29±13.46)(μg·h)/L. Conclusion:absorption and elimination of Sinomenine were quickly and Tmax is short

concentration of drug is high in rabbits after intragastric administration.

关键词

青藤碱家兔高效液相色谱药代动力学

Keywords

SinomeninerabbitHPLCpharmacokinetics

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