The effect of pridoxamine on erectile function in diabetic rats

PU Xiao-feng; et al

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The effect of pridoxamine on erectile function in diabetic rats

更新时间：2024-01-17

- The effect of pridoxamine on erectile function in diabetic rats
- Journal of Chongqing Medical University Issue 8, Pages: 976-979(2008)
- 作者机构：
  
  重庆医科大学附属第一医院泌尿外科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R698.1
- Published：2008，
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[1]蒲晓峰,苟欣,刘德云,杨华安,郑传东.吡哆胺对糖尿病大鼠勃起功能影响的实验研究[J].重庆医科大学学报,2008(08):976-979.

PU Xiao-feng, et al. The effect of pridoxamine on erectile function in diabetic rats. [J]. Journal of Chongqing Medical University (8):976-979(2008)
[1]蒲晓峰,苟欣,刘德云,杨华安,郑传东.吡哆胺对糖尿病大鼠勃起功能影响的实验研究[J].重庆医科大学学报,2008(08):976-979. DOI：

PU Xiao-feng, et al. The effect of pridoxamine on erectile function in diabetic rats. [J]. Journal of Chongqing Medical University (8):976-979(2008) DOI：

摘要

目的:探讨吡哆胺对糖尿病大鼠勃起功能的影响。方法:通过腹腔注射STZ建立糖尿病大鼠模型

然后随机分成DM组和DM+PM组

DM+PM组每天用吡哆胺200mg/kg灌胃干预。12周后观察各组大鼠勃起功能

并获取阴茎海绵体组织检测一氧化氮（Nitric Oxide

NO）、一氧化氮合酶（Nitric oxide synthase

NOS）与环磷酸鸟苷（cGMP）水平。结果:成功建立糖尿病大鼠模型。与未使用吡哆胺灌胃干预的DM组相比

正常对照组（C组）和DM+PM组勃起功能更好

3个实验组大鼠勃起率分别是46.2%

100%和71.4%。C组和DM+PM组NO水平明显比DM组高

3个组含量分别是（7.82±0.77）、（6.47±0.54）和（3.23±0.28）μmol/gpro（tP<0.05）;NOS活力在DM组为（0.69±0.11）U/mgprot

较C组（2.00±0.30）U/mgprot和DM+PM组（1.07±0.15）U/mgprot明显降低（P<0.05）。cGMP含量在DM组为（36.15±1.94）pmol/ml

显著低于C组（54.19±2.62）pmol/ml和DM+PM组（50.57±1.20）pmol/m（lP<0.05）。结论:吡哆胺通过作用于L-Arg-NO-cGMP通路对糖尿病大鼠勃起功能有一定保护作用。

Abstract

Objective:To investigate the effect of pridoxamine on erectile function in diabetic rats.Methods:Male adult Sprague-Dawley rats were induced for diabetes by an intraperitoneal injection of streptozotocin

then randomly divided into DM group and DM+PM group.The rats in DM+PM group were treated with pridoxamine at a dosage of 200mg/kg through a gastric perfusion every day.Twelve weeks later the erectile function of all these rats were evaluated

and their penises tissues were harvested.The NO

NOS

and cGMP levels in corpus cavernosum were measured.Results:The diabetic rat model was successfully established.The erectile function was much better in normal control group(group C

100%) and DM+PM group(71.4%)than in DM group(46.2%)(P<0.05).The NO level in DM group was significantly decreased(3.23±0.28)μmol/gprot

compared with group C(7.82±0.77)μmol/gprot and DM+PM group(6.47±0.54)μmol/gprot(P<0.05).The NOS level in group C(2.00±0.30)U/mgprot and DM+PM group(1.07±0.15)U/mgprot was both much higher than in DM group(0.69±0.11)U/mgprot(P<0.05).The cGMP content in corpus cavemosum was markedly decreased in DM group(36.15±1.94)pmol/ml

compared with group C(54.19±2.62)pmol/ml and DM+PM group(50.57±1.20)pmol/ml

(P<0.05).Conclusion:The pridoxamine has some effect of L-Arg-NO-cGMP pathway on diabetic rats’penis tissues

and may play some role in protecting the harm to erectile function caused by diabeties.

关键词

勃起功能糖尿病吡哆胺大鼠

Keywords

Erectile functiondiabetesPridoxaminerats

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