Objective:To investigate the clinical efficacy of deliberate hypotension with remifentanil in endovascular treatment of intracranial aneurysms.Methods:A total of 30 cases of intracranial aneurysms

were divided according to the condition of combined with hypertension

into control group(Group C) and hypertension group(Group H)

each with 15 cases.Two groups adopted induction of anesthesia in patients with intravenous propofol 1.5～2mg/kg

remifentanil 1μg/kg

vecuronium 0.1mg/kg.Maintenance of anesthesia:propofol 3~5mg/(kg·h) and remifentanil 0.2～0.4μg/(kg·min)

and intermittent intravenous injection of vecuronium 0.06mg/kg maintained muscle relaxation.When controlled hypotension was needed

the infusion of remifentanil to accelerated 0.8μg/(kg·min).Heart rate and blood pressure were recorded at baseline

after anesthesia induction

on tracheal intubation

before intracranial aneurysm embolism

after intracranial aneurysm embolism and extubation.Results:After induction of anesthesia

there were obvious decline in blood pressure and heart rate in both group(P<0.05).The BP and HR of Group C were stable in the whole progress of operation

while BP Group H often increased before intracranial aneurysm embolism and needed controlled hypotension with sodium nitroprusside and incidence of hypertension was higher than that of N group(P<0.05).Conclusion:Controlled hypotension with remifentanil was safe and pratical for non-hypertension patients

but it was not enough only with remifentanil for hypertension patients

which needed other drug such as sodium nitroprusside.