Retrospective approach on clinical feature and effected prognostic factor of cavitas nasi primarily non-Hodgkin’s lymphoma NHL in 38 cases

ZHONG Xiao-hong; et al

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Retrospective approach on clinical feature and effected prognostic factor of cavitas nasi primarily non-Hodgkin’s lymphoma NHL in 38 cases

更新时间：2024-01-17

- Retrospective approach on clinical feature and effected prognostic factor of cavitas nasi primarily non-Hodgkin’s lymphoma NHL in 38 cases
- Journal of Chongqing Medical University Issue 9, Pages: 1138-1140(2008)
- 作者机构：
  
  重庆市肿瘤研究所头颈科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R739.6
- Published：2008，
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[1]周小红,葛家华,何云.38例鼻腔原发非霍奇金氏淋巴瘤NHL的临床特征和影响预后的因素回顾性探讨[J].重庆医科大学学报,2008(09):1138-1140.

ZHONG Xiao-hong, et al. Retrospective approach on clinical feature and effected prognostic factor of cavitas nasi primarily non-Hodgkin’s lymphoma NHL in 38 cases. [J]. Journal of Chongqing Medical University (9):1138-1140(2008)
[1]周小红,葛家华,何云.38例鼻腔原发非霍奇金氏淋巴瘤NHL的临床特征和影响预后的因素回顾性探讨[J].重庆医科大学学报,2008(09):1138-1140. DOI：

ZHONG Xiao-hong, et al. Retrospective approach on clinical feature and effected prognostic factor of cavitas nasi primarily non-Hodgkin’s lymphoma NHL in 38 cases. [J]. Journal of Chongqing Medical University (9):1138-1140(2008) DOI：

摘要

目的:分析鼻腔原发非霍奇金氏淋巴瘤（Non-Hodgkin’s lymphoma

NHL）的临床特征和影响预后的因素。方法:回顾性研究本院38例原发于鼻腔及鼻窦的NHL的临床特点、诊断及治疗。结果:38例患者按照An Arbor分期

Ⅰ期14例

Ⅱ期11例

Ⅲ期7例

Ⅳ期6例

就诊主要症状为鼻塞、流涕和鼻衄等

11例伴有发热、盗汗或体重下降等全身症状。38例患者淋巴瘤细胞为小细胞至大细胞性等多种类型

病变内常见坏死改变

25例进行免疫表型分析

全部为T细胞性。除6例早期患者单独放疗、7例化疗外

其余25例采用放化疗综合治疗。全组5年生存率78.9%

早期局限病变（Ⅰ、Ⅱ期组）92.0%

晚期病变（Ⅲ、Ⅳ期）为53.8%

两组生存率差别显著（χ2=11.29

P<0.001）。结论:临床分期为鼻腔原发NHL的主要预后因素

早期局限病变疗效较好;晚期病变发展迅速

常规治疗预后差

应探索更为有效的治疗策略。

Abstract

Objective:To investigate the clinical characteristics and prognostic factors of patients with primary nasal non-Hodgkin’s lymphoma(NHL). Methods:The clinical features

diagnosis and treatment of 38 patients with NHL occurring in nasal cavities and paranasal sinuses were retrospectively analyzed. Results:The Ann Arbor stages were:stage Ⅰ

14patients; stage Ⅱ

11 patients;stage Ⅲ

7 patients;stage Ⅳ

6 patients. The most common symptoms at the presentation included nasal obstruction

rhinorrhea and cpistaxis. 11 patients had B symptoms(fever

night sweat

and/or weight loss). The lymphoma cells in all the cases ranged in size from small to large

and necrosis was common. Immunophenotyping were determined in 25cases and all were T cell type. 6 cases with early localized-disease were treated with radiotherapy and 7 had chemotherapy

the remaining 25 cases received combined chemotherapy and radiotherapy. The 5-year overall survival(OS) for the entire group was 78.9%

and those for patients with localized disease(stages Ⅰ and Ⅱ) and those with the advanced disease(stages Ⅲ and Ⅳ) were 92.0% and 53.8%

respectively(χ2=11.29

P<0.001). Conclusions:Stage of disease is a strong predictor of outcome for primary nasal NHL. The patients with localized disease had a relatively favorable prognosis. The advanced disease may progress rapidly and have unfavorable prognosis if it were treated with conventional chemotherapy

and therefore

further studies are required to improve the outcome.

关键词

非霍奇金氏淋巴瘤鼻腔诊断预后

Keywords

Non-Hodgkin’s lymphomaNasal cavitydiagnosisprognosis

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Department of Intensive Medicine（Comprehensive ICU），The First Affiliated Hospital of Gannan Medical University，Jiangxi Provincial Key Clinical Specialized Department of Intensive Medicine

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Department of Otolaryngology-Head and Neck Surgery, Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics

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