Propofol anesthesia with target-controlled influsion technic modulated by cerebral state index in the elderly patients with tumor

LEI Xiao-feng; et al

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Propofol anesthesia with target-controlled influsion technic modulated by cerebral state index in the elderly patients with tumor

更新时间：2024-01-17

- Propofol anesthesia with target-controlled influsion technic modulated by cerebral state index in the elderly patients with tumor
- Journal of Chongqing Medical University Issue 6, Pages: 730-732(2008)
- 作者机构：
  
  1. 重庆市肿瘤研究所麻醉科
  2. 重庆市肿瘤研究所麻醉科,重庆,400030
- 作者简介：
- 基金信息：
- DOI：
  CLC： R614
- Published：2008，
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[1]雷晓峰,邓永乐,唐延先,龙勤,段礼平.麻醉深度指数反馈调控老年肿瘤患者靶控输注丙泊酚麻醉的研究[J].重庆医科大学学报,2008(06):730-732.

LEI Xiao-feng, et al. Propofol anesthesia with target-controlled influsion technic modulated by cerebral state index in the elderly patients with tumor. [J]. Journal of Chongqing Medical University (6):730-732(2008)
[1]雷晓峰,邓永乐,唐延先,龙勤,段礼平.麻醉深度指数反馈调控老年肿瘤患者靶控输注丙泊酚麻醉的研究[J].重庆医科大学学报,2008(06):730-732. DOI：

LEI Xiao-feng, et al. Propofol anesthesia with target-controlled influsion technic modulated by cerebral state index in the elderly patients with tumor. [J]. Journal of Chongqing Medical University (6):730-732(2008) DOI：

摘要

目的:研究麻醉深度指数（Cerebral state inder

CSI）反馈调控老年肿瘤患者靶控输注（Target controlled infusion

TCI）丙泊酚的效果。方法:胃癌及直肠癌根治术126例

年龄≥65岁

ASAⅠ～Ⅱ级

随机分为反馈靶控组和靶控组

每组各63例。反馈组设定CSI=50

两组丙泊酚的血浆靶浓度设定为2μg/ml

舒芬太尼的血浆靶浓度麻醉诱导时1.5ng/ml

麻醉维持时0.3ng/ml。记录基础值（T1）、插管（T2）、插管后5min（T3）、切皮（T4）、肿瘤切除（T5）和手术结束（T6）等时点的MAP、HR、HRV和CSI值的变化

统计丙泊酚的用量。结果:靶控组在插管后5min（T3）、切皮（T4）、切肿瘤（T5）等时点的MAP下降比反馈靶控组明显（P<0.05）;HRV在插管后5min（T3）、肿瘤切除（T5）时下降较反馈靶控组明显（P<0.05）;反馈靶控组的CSI值波动小于靶控组（P<0.05）

丙泊酚的用量也小于靶控组（P<0.05）。结论:麻醉深度指数反馈调控靶控输注丙泊酚对老年肿瘤患者的麻醉安全可行。

Abstract

Objective:To study the clinical benefit of propofol anesthesia with target-controlled influsion technic modulated by cerebral state index in the elderly patients with tumor. Methods:A total of 126 ASA Ⅰ or Ⅱ aged65 yrs or older patients underwent gastrectomy and rectal surgery were randomly divided into tow groups(n=63 each):group by target-controlled influsion technic modulated(groupⅠ)and group by target-controlled influsion(groupⅡ). CSI of groupⅠwas 50. Propofol of two groups was administered by TCI at a target blood concertration of 2μg/ml during induction of anesthesia and maintenance of anesthesia

sufentanil of two groups was administered by TCI at a target blood concertration of 1.5μg/ml during induction of anesthesia and of 0.3ng/ml during maintenance of anesthesia. MAP

HRV and CSI of the foundation(T1)

intubation(T2)

five minutes after intubation(T3)

chip(T4)

the tumor excision(T5) and the end of surgery(T6) were recorded. And the total of propofol was recorded. Results:MAP at T3

T4 and T5 of groupⅡdecreased obviously compared to that of groupⅠ(P<0.05); HRV of groupⅠat T4 and T5 decreased obviously compared to that of groupⅠ(P<0.05);The undulation with CSI of groupⅠwas less than that of groupⅡ(P<0.05)

the total propofol of groupⅡwas less than that of groupⅠ(P<0.05).Conclusion:Propofol anesthesia with target-controlled influsion technic modulated by cerebral state index in the elderly patients with tumor was safe and applicable.

关键词

麻醉意识深度指数靶控输注丙泊酚老年肿瘤患者

Keywords

Cerebral state indextarget controlled infusionpropofolThe elderly patients with tumor

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