Establishment of rabbit endocarditis models caused by enterococcus

WU Li-xian; et al

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Establishment of rabbit endocarditis models caused by enterococcus

更新时间：2024-01-17

- Establishment of rabbit endocarditis models caused by enterococcus
- Journal of Chongqing Medical University Issue 4, Pages: 437-440(2008)
- 作者机构：
  
  1. 重庆医科大学附属第一医院感染科,重庆市传染病寄生虫病学重点实验室
  2. 重庆医科大学科研处
- 作者简介：
- 基金信息：
- DOI：
  CLC： R-332
- Published：2008，
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[1]吴利先,黄文祥,伍群,罗涛,孙小平.肠球菌兔心内膜炎模型的建立[J].重庆医科大学学报,2008(04):437-440.

WU Li-xian, et al. Establishment of rabbit endocarditis models caused by enterococcus. [J]. Journal of Chongqing Medical University (4):437-440(2008)
[1]吴利先,黄文祥,伍群,罗涛,孙小平.肠球菌兔心内膜炎模型的建立[J].重庆医科大学学报,2008(04):437-440. DOI：

WU Li-xian, et al. Establishment of rabbit endocarditis models caused by enterococcus. [J]. Journal of Chongqing Medical University (4):437-440(2008) DOI：

摘要

目的:建立肠球菌毒力相关性兔心内膜炎模型

用于肠球菌类毒力因子的研究。方法:用粪肠球菌（Enterococcus faecalis）标准毒株OG1RF和粪肠球菌sprE基因缺陷突变株来建立兔心内膜炎模型

通过心内膜炎相关指标的检测来判断毒力下降情况。结果:突变株在兔心内膜炎模型中产生赘生物的大小、重量以及菌落计数都明显低于标准株。结论:肠球菌毒力相关性兔心内膜炎模型建立成功

可用于肠球菌其他可能毒力因子的研究。

Abstract

objective:To establish Rabbit endocarditis models caused by Enterococcus faecalis for studying virulence of Enterococcus.Methods:Standard strain OG1RF and sprE gene deficient mutant of Enterococcus faecalis were used to establish Rabbit endocarditis models.The index of endocarditis was detected to show virulence change.Results:The size

weight and Colony count of vegetation of sprE mutant groups were smaller than those of wild-type OG1RF groups in a rabbit endocarditis model.Conclusion:The Rabbit endocarditis models caused by Enterococcus were establised successfully

which would be used to study other virulence factor of Enterococcus faecalis.

关键词

肠球菌毒力心内膜炎模型

Keywords

EnterococcusVirulenceEndocarditis models

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Department of Infectious Diseases,the First Affiliated Hospital,Chongqing Medical University

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