Study on injury in brain parenchyma surrounding intracebral hemorrhage induced by iron ions

LIU Sheng-shan; et al

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Study on injury in brain parenchyma surrounding intracebral hemorrhage induced by iron ions

更新时间：2024-01-17

- Study on injury in brain parenchyma surrounding intracebral hemorrhage induced by iron ions
- Journal of Chongqing Medical University Issue 6, Pages: 700-703(2008)
- 作者机构：
  
  1. 重庆医科大学附属第二医院神经内科
  2. 重庆医科大学附属第二医院神经内科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：
  CLC： R743.34
- Published：2008，
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[1]刘圣山,李长清.铁离子致脑出血后血肿周围组织损伤研究[J].重庆医科大学学报,2008(06):700-703.

LIU Sheng-shan, et al. Study on injury in brain parenchyma surrounding intracebral hemorrhage induced by iron ions. [J]. Journal of Chongqing Medical University (6):700-703(2008)
[1]刘圣山,李长清.铁离子致脑出血后血肿周围组织损伤研究[J].重庆医科大学学报,2008(06):700-703. DOI：

LIU Sheng-shan, et al. Study on injury in brain parenchyma surrounding intracebral hemorrhage induced by iron ions. [J]. Journal of Chongqing Medical University (6):700-703(2008) DOI：

摘要

目的:研究脑出血后血红蛋白的代谢产物铁离子在血肿周围组织损伤中的作用及去铁胺的干预影响。方法:将SD大鼠随机分为假手术组、脑出血组和去铁胺干预组

以自体血大鼠尾状核注射为模型

观察各组大鼠建模术后不同时间点神经功能评分、脑组织含水量和血脑屏障通透性变化、血清S100B蛋白和神经元特异性烯醇化酶（Neuron-specific-enolas

NSE）水平及去铁胺干预的影响。结果:与对照组比较

脑出血模型大鼠在建模术后1～7d存在明显神经功能障碍

血肿周围脑组织水份含量明显增加

血脑屏障通透性明显增高

血清S100B蛋白和NSE水平明显升高。去铁胺干预组模型大鼠各观察指标与脑出血模型大鼠呈现相同变化趋势

但神经功能评分明显低于脑出血组

血肿周围脑组织水份含量明显低于脑出血组

血脑屏障通透性明显低于脑出血组

血清S100B蛋白和NSE水平明显低于脑出血组。结论:脑出血后铁离子异常积聚参与了脑出血后血肿周围组织的损伤

去铁胺对这种损伤有保护作用。

Abstract

Objective:To investigate the role of iron ions released by metabolism products of haemoglobin after intracerebral hemorrhage(ICH) in the injury of surrounding brain parenchyma and the influence of intervention by deferoxamine(DFO). Methods:Sprague-Dawley rats were randomly divided into the sham operation groups、intracebral hemorrhage(ICH) groups and deferoxamine groups

and received infusion of autologous blood. Evaluation on neurological function

brain water content

the permability of blood brain barrier

S100B proteins

neuron-specific-enolas(NSE) and the influence of intervention by deferoxamine were detected at different time points after operation. Results:Compared with the sham operation groups

the rats of ICH groups had significantly neurological disorder and the increase of brain water content surrounding brain parenchyma

the permeability of blood brain barrier

S100B protein and NSE of blood serum. The rats of DFO groups had the same trend with the rats of ICH groups in all kinds of observed items but neurological function scores test

brain water content surrounding brain parenchyma

the permeability blood brain barrier

S100B protein and NSE of blood serum were lower than those of ICH groups. Conclusion:The abnormal accumulation of iron ions participates the injury of brain tissue surrounding brain parenchyma after ICH and deferoxamine has the protective role for the injury.

关键词

铁脑出血去铁胺

Keywords

Ironintracerebral hemorrhageDeferoxamine

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Teaching and Research Section of Anatomy,College of Basic Medical Sciences

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Teaching and Research Section of Anatomy，College of Basic Medicine，Chongqing Medical University

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