Expressions of cyclinE,cdk2 and p27<sup>kip1</sup> in invasive pituitary adenomas and the clinical significance

您当前的位置：

首页 >

文章列表页 >

Expressions of cyclinE,cdk2 and p27^kip1 in invasive pituitary adenomas and the clinical significance

更新时间：2024-01-17

|

- Expressions of cyclinE,cdk2 and p27^kip1 in invasive pituitary adenomas and the clinical significance
- Journal of Chongqing Medical University Issue 9, Pages: 1118-1120(2008)
- 作者机构：
  
  重庆医科大学附属第一医院神经外科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R736.4
- Published：2008，
扫描看全文
[1]郑安锡,霍钢,郑履平.侵袭性垂体腺瘤中cyclinE、cdk2和p27~(kip1)的表达及其临床意义[J].重庆医科大学学报,2008(09):1118-1120+1129.

ZHENG An-xi, et al. Expressions of cyclinE,cdk2 and p27^kip1 in invasive pituitary adenomas and the clinical significance. [J]. Journal of Chongqing Medical University (9):1118-1120(2008)
[1]郑安锡,霍钢,郑履平.侵袭性垂体腺瘤中cyclinE、cdk2和p27~(kip1)的表达及其临床意义[J].重庆医科大学学报,2008(09):1118-1120+1129. DOI：

ZHENG An-xi, et al. Expressions of cyclinE,cdk2 and p27^kip1 in invasive pituitary adenomas and the clinical significance. [J]. Journal of Chongqing Medical University (9):1118-1120(2008) DOI：

摘要

目的:探讨cyclinE、cdk2和p27kip1在侵袭性垂体腺瘤中的表达情况及其与临床生物学行为的关系。方法:采用western blotting法检测37例非侵袭性垂体腺瘤和21例侵袭性垂体腺瘤中cyclinE、cdk2和p27kip1蛋白的表达情况。结果:cyclinE和cdk2在侵袭组中的表达均明显高于非侵袭组（P均<0.01）

而p27kip1在侵袭组中的表达明显低于非侵袭组（P<0.01）;cyclinE和cdk2在垂体腺瘤中的表达呈正相关（P<0.01）

两者与p27的表达均呈负相关（P均<0.01）;cyclinE和cdk2的表达与垂体腺瘤的侵袭性均呈正相关（P均<0.01）

p27的表达与垂体腺瘤的侵袭性呈负相关（P<0.01）。结论:cyclinE和cdk2的过度表达和p27kip1的低表达与侵袭性垂体腺瘤的增殖、发生、发展显著相关

三者可能成为判断垂体腺瘤的侵袭性和预后的指标。

Abstract

Objective:To study the expressions of cyclinE

cdk2 and p27kip1 in invasive pituitary adenomas and their relation to clinical biological behaviors. Methods:Western blotting analysis was adopted to detect the expressions of cyclinE

cdk2 and p27kip1 in 37 cases of noninvasive pituitary adenomas and 21 cases of invasive pituitary adenomas. Results:The expressions of cyclinE and cdk2 in invasive pituitary adenomas were significantly higher than those in noninvasive pituitary adenomas(both P<0.01)

but the expression of p27kip1 in invasive group was significantly lower than that in noninvasive group(P<0.01). There were positive correlation between the expressions of cyclinE and cdk2 in pituitary adenomas(P<0.01)

and negative correlation between the former two and p27(both P<0.01);there were positive correlation between the expressions of cyclinE and cdk2 and the invasiveness of pituitary adenomas(both P<0.01)

and negative correlation between the expression of p27 and the invasiveness of pituitary adenomas(P<0.01). Conclusion:The overexpression of cyclinE and cdk2 and the lower expression of p27kip1 were significantly associated with the proliferation

incidence and development of the invasive pituitary adenomas

and cyclinE

cdk2 and p27kip1 proteins may be valuable invasive and prognostic factors for pituitary adenoma.

关键词

垂体腺瘤侵袭cyclinECDK2p27kip1

Keywords

pituitary adenomaInvasivenesscyclinECDK2p27kip1

references

0

Views

76

下载量

0

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Related Articles

An analysis of risk factors for preoperative hypofunction of the HPA and HPT axes in patients with pituitary adenoma and their postoperative outcomes

Expression of PTEN,MMP-9 and P27kip1 in breast cancer and their clinical significance

Expression of p27^kip1,skp2,p53 gene in colorectal adenocarcinoma and its significance

Expressions of PLGF and VEGFR-1 in invasive pituitary adenoma

Effects of rosiglitazone on neointimal hyperplasia and the expression of c-Fos and p27^kip1 in rat carotid arteries after balloon injure

Related Author

Chen Yong

Zheng Xin

Yang Hui

Li Song

Zhang Xiaoqing

郭慧琳

et al

YANG Xiao-qiong

Related Institution

Department of Neurosurgery，Xinqiao Hospital，Army Medical University

Department of Oncology,the First Affiliated Hospital,Chongqing Medical University

Department of Pathology, Molecular Medicine and Tumor Research Center,Chongqing Medical University

Department of Cardiology,The First Affiliated Hospital,Chongqing Medical University

Key Laboratory of Diagnostic Medicine Founded by Ministry of Education，Institute of Laboratory Medicine，Chongqing Medical University

⁰