Expression of caraiomyocyte angiotensin Ⅱ receptors in rat with pressure over load-induced left ventricular hypertrophy

WANG Yu-bing; et al

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Expression of caraiomyocyte angiotensin Ⅱ receptors in rat with pressure over load-induced left ventricular hypertrophy

更新时间：2024-01-17

- Expression of caraiomyocyte angiotensin Ⅱ receptors in rat with pressure over load-induced left ventricular hypertrophy
- Journal of Chongqing Medical University Issue 9, Pages: 1050-1053(2008)
- 作者机构：
  
  1. 四川省南充市川北医学院附属医院心内科
  2. 重庆医科大学附属第一医院心内科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R541.3
- Published：2008，
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[1]王玉兵,陈明.压力超负荷左室肥厚大鼠心肌组织血管紧张素Ⅱ受体的表达[J].重庆医科大学学报,2008(09):1050-1053+1135.

WANG Yu-bing, et al. Expression of caraiomyocyte angiotensin Ⅱ receptors in rat with pressure over load-induced left ventricular hypertrophy. [J]. Journal of Chongqing Medical University (9):1050-1053(2008)
[1]王玉兵,陈明.压力超负荷左室肥厚大鼠心肌组织血管紧张素Ⅱ受体的表达[J].重庆医科大学学报,2008(09):1050-1053+1135. DOI：

WANG Yu-bing, et al. Expression of caraiomyocyte angiotensin Ⅱ receptors in rat with pressure over load-induced left ventricular hypertrophy. [J]. Journal of Chongqing Medical University (9):1050-1053(2008) DOI：

摘要

目的:本研究观察压力超负荷左室肥厚（Left ventricular hypertrophy

LVH）大鼠心肌组织AT1和AT2的表达

进一步探讨血管紧张素Ⅱ（AngiotensinⅡ

AngⅡ）受体在左室肥厚中的作用及可能机制。方法:采用腹主动脉缩窄法建立LVH模型

14只Sprague-Dawley（SD）大鼠随机分为:（1）假手术组（n=7）;（2）手术组（手术组n=7）;用免疫组化法及RT-PCR检测血管紧张素Ⅱ受体（AT）的表达

同时检测LVH的指标:心肌纤维化、左室质量指数（LVMI）、心肌细胞横切面积（CSA）、心肌细胞凋亡指数。结果:与假手术组比较

手术组SBP、DBP、MBP、LVMI、心肌细胞CSA、心肌细胞凋亡指数（Apoptosis index

APOI）、血浆AngⅡ水平及AT1和AT2蛋白和mRNA的表达水平均显著升高。结论:左室肥厚大鼠心肌组织AT1和AT2从蛋白和mRNA表达水平均明显升高;AT1和AT2均参与左室肥厚过程

但二者可能发挥相互拮抗的作用。

Abstract

Objective:To investigate the role of AngⅡreceptors(AT1 and AT2) in the left ventricular hypertrophic process and its mechanisms through detecting the expression of AngⅡreceptors(AT1 and AT2) in hypertrophic cardiomyocyte induced by pressure overload in rats. Methods:Fourteen Male Sprague-Dawley rats were divided into two groups: sham group(n=7)

and operation group(n=7). Left ventricular hypertrophy model was well established after abdominal aortic stenosis in each group.The expression of AT1 and AT2 was detected by immunohistochemistry(IHC) and RT-PCR

respectively. Indexes of left ventricular hypertrophy

including myocardial fibrosis

LVMI

cross-sectional area and apoptosis index(APOI)

were also measured. Results: SBP

DBP

MBP

LVMI

and cardiomyocyte CSA

APOI

level of plasma AngⅡand expression of AT1 and AT2 in operation group were markedly increased as compared with sham group. Conclusion:Expression of cardiomyocyte AT1 and AT2 receptors were increased significantly in rat of left ventricular hypertrophy

which indicated that AT1 and AT2 receptors both participate in the process of left ventricular hypertrophy but they may play antagonism effects.

关键词

左室肥厚血管紧张素Ⅱ受体

Keywords

left ventricular hypertrophyAng ⅡReceptor

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