Anoxia-reoxygenation up-regulates transcription of TGFβ<sub>1</sub> gene in human umbilical veins endothelial cell line

YIN Zhi-kang; et al

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Anoxia-reoxygenation up-regulates transcription of TGFβ₁ gene in human umbilical veins endothelial cell line

更新时间：2024-01-17

- Anoxia-reoxygenation up-regulates transcription of TGFβ₁ gene in human umbilical veins endothelial cell line
- Journal of Chongqing Medical University Issue 6, Pages: 694-696(2008)
- 作者机构：
  
  1. 重庆医科大学附属第一医院泌尿外科
  2. 重庆医科大学附属第一医院泌尿外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R699
- Published：2008，
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[1]尹志康,吴小候,何云峰,刘川,杜虎.缺氧再给氧上调人血管内皮细胞TGFβ_1的基因转录[J].重庆医科大学学报,2008(06):694-696.

YIN Zhi-kang, et al. Anoxia-reoxygenation up-regulates transcription of TGFβ₁ gene in human umbilical veins endothelial cell line. [J]. Journal of Chongqing Medical University (6):694-696(2008)
[1]尹志康,吴小候,何云峰,刘川,杜虎.缺氧再给氧上调人血管内皮细胞TGFβ_1的基因转录[J].重庆医科大学学报,2008(06):694-696. DOI：

YIN Zhi-kang, et al. Anoxia-reoxygenation up-regulates transcription of TGFβ₁ gene in human umbilical veins endothelial cell line. [J]. Journal of Chongqing Medical University (6):694-696(2008) DOI：

摘要

目的:探讨缺氧再给氧对人血管内皮细胞中的TGFβ1基因转录的影响。方法:建立人脐静脉内皮细胞株的缺氧再给氧模型

采用改良的RT-PCR

半定量分析缺氧再给氧后内皮细胞中TGFβ1的mRNA的变化。结果:缺氧再给氧组与对照组相比

TGFβ1的mRNA明显升高。结论:缺氧再给氧上调血管内皮细胞TGFβ1基因的转录。

Abstract

Objective:To investigate the influence of anoxia-reoxygenation on the transcription of TGFβ1 gene in Human umbilical veins endothelial cell line(ECV304). Methods:Anoxia-reoxygenation model of Human umbilical veins endothelial cell line was established. TGFβ1 mRNA was half-quantitatively analyzed by a modified RT-PCR. Results:The transcription of TGFβ1 mRNA was up-regulated significantly in anoxia-reoxygenation group compared with the control group. Conclusion: anoxia-reoxygenation may up-regulate the transcription of TGFβ1 gene in human umbilical veins endothelial cell line.

关键词

缺氧再给氧人脐静脉内皮细胞TGFβ1

Keywords

Anoxia-reoxygenationHuman umbilical veins endothelial cell lineTransforming growth factor-beta-1

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Anoxia-reoxygenation up-regulates transcription of TGFβ1 gene in human umbilical veins endothelial cell line

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references

Anoxia-reoxygenation up-regulates transcription of TGFβ₁ gene in human umbilical veins endothelial cell line