The effects of taurine on the expression of Caspase-3 and NF-κB in dorsal root ganglion diabetic rats

YE Ren-qun; et al

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The effects of taurine on the expression of Caspase-3 and NF-κB in dorsal root ganglion diabetic rats

更新时间：2024-01-17

- The effects of taurine on the expression of Caspase-3 and NF-κB in dorsal root ganglion diabetic rats
- Journal of Chongqing Medical University Issue 8, Pages: 923-926(2008)
- 作者机构：
  
  1. 深圳市宝安区中医院内科
  2. 中南大学湘雅医院中西医结研究所
  3. 深圳市第三人民医院内科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R587.2
- Published：2008，
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[1]叶仁群,陈泽奇,林国彬,张清梅,李玉红,贺钰磊.牛磺酸对糖尿病大鼠背根节细胞Caspase-3和NF-κB表达的影响[J].重庆医科大学学报,2008(08):923-926+930.

YE Ren-qun, et al. The effects of taurine on the expression of Caspase-3 and NF-κB in dorsal root ganglion diabetic rats. [J]. Journal of Chongqing Medical University (8):923-926(2008)
[1]叶仁群,陈泽奇,林国彬,张清梅,李玉红,贺钰磊.牛磺酸对糖尿病大鼠背根节细胞Caspase-3和NF-κB表达的影响[J].重庆医科大学学报,2008(08):923-926+930. DOI：

YE Ren-qun, et al. The effects of taurine on the expression of Caspase-3 and NF-κB in dorsal root ganglion diabetic rats. [J]. Journal of Chongqing Medical University (8):923-926(2008) DOI：

摘要

目的:观察牛磺酸对糖尿病大鼠背根节细胞中Caspase-3和NF-κB mRNA表达的影响

并探讨其神经保护作用的机制。方法:40只Wistar大鼠

8只作为正常对照组

其他以链脲佐菌素（Streptozotocin

STZ）诱发糖尿病模型。糖尿病模型建立成功后

随机分组为模型组（DM）和牛磺酸治疗组（TA）

其下又各设4周、8周亚组

应用RT-PCR法检测背根节细胞中Caspase-3和NF-κB的mRNA表达。结果:在正常鼠组织中弱表达Caspase-3和NF-κB mRNA

4周、8周后DM组二者表达增加

牛磺酸治疗组中

Caspase-3和NF-κB的mRNA表达与同期模型组比较其表达均有下降（P<0.05）。结论:牛磺酸的神经保护作用可能与其抑制NF-κB的活化

下调Caspase-3基因的表达

从而抑制神经组织细胞凋亡有关。

Abstract

Objective:To investigate the effect of Taurine on the expression of Caspase-3 and NF-κB in dorsal root ganglion of diabetic rats and explore its mechanism of nervous protective effect.Methods:Among 40 healthy male wistar rats

8 were used as control

and diabetes were induced on the other rats by the intraperitoneal injection of streptozotocin(STZ) at a doze of 50mg/kg.Diabetes were characterized by an increase in blood glucose(>16.7mmol/L)48hours after injection.The successful diabetic rats models were randomly divided into diabetic mellitus(DM) group and taurine(TA) group.DM and TA groups were subdivided into DM1

DM2 and TA1

TA2 groups according to the duration of diabetes.The expression of Caspase-3 and NF-κB mRNA were studied by reverse-transcriptase polymerase chain reaction(RT-PCR) method.Results:NO obvious expression of Caspase-3 and NF-κB mRNA were found in the nomal groups compared with DM group after the 4th and 8th week.Under the intervention of taurine

the expression of Caspase-3 and NF-κB mRNA were inhibited compared with those in model.group(P<0.05).Conclusion:Taurine can inhibit apoptosis of the dorsal root ganglion induced by streptozotocin(STZ) by inhibiting the activation of NF-κB and down-regulating Caspase-3 gene.

关键词

糖尿病周围神经病变细胞凋亡Caspase-3NF-κB大鼠

Keywords

diabetic peripheral neuropathyapoptosisCaspase-3NF-κBrat

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