Objective:To analyze CT and MRI manifestations of cranium and spinal column with neurofibromatosis type1 and 2 to improve the diagnostic accuracy.Methods:CT and MRI images of 16 cases of neurofibromatosis confirmed by clinics and pathology were analyzed retrospectively.2 cases were examined by CT and 14 cases by MRI.There were 6 cases of NF1 and 10 cases of NF2.The abnormal CT and MRI manifestations of the lesions were analyzed.Results:NF1 manifestations were as follows:5 cases of multiple schwannomas were displayed on MRI with intraspinal and paraspinal lesions

and along with 1 case of syringomyelia

2 cases of right great psoas muscle schwannomas.1 case had defect of right great wing of the sphenoid on CT.NF2 manifestations were as follows:5 cases had bilateral acoustic neuromas and multiple meningioms

and with 2 cases of multiple neurofibromas in the occipital

cervical and lumbar soft tissues;2 cases of bilateral internal auditory canal enlarged on CT;1 case of choroid plexus in the lateral ventricle abnormal calcification

1case of right troehlear nerve schwannoma.5 cases had single acoustic neuromas

with 3 cases of schwannomas in spinal canal

and 1case of intramedullary cervical spinal cord ependymoma and syringomyelia;3 cases of multiple meningioms and with 1 case of schwannoma on the facial nerve

vestibular and trigemina nerve;and 3 cases had abnormal signal lesions in the brain parenchyma.Conclusion:Neurofibromatosis type 1 and 2 had characteristic CT and MRI manifestations in cranium and spinal column

which could be diagnosed correctly in clinic.