Oxygen free radical damage and it’s effect on ultrastructure result in erection dysfunction on diabetes mellitus rat

LIU De-yun; et al

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Oxygen free radical damage and it’s effect on ultrastructure result in erection dysfunction on diabetes mellitus rat

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- Oxygen free radical damage and it’s effect on ultrastructure result in erection dysfunction on diabetes mellitus rat
- Journal of Chongqing Medical University Issue 9, Pages: 1042-1046(2008)
- 作者机构：
  
  重庆医科大学附属第一医院泌尿外科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R698.1
- Published：2008，
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[1]刘德云,苟欣,蒲晓峰.糖尿病大鼠氧自由基损伤和对超微结构影响致勃起功能障碍的研究[J].重庆医科大学学报,2008(09):1042-1046+1083.

LIU De-yun, et al. Oxygen free radical damage and it’s effect on ultrastructure result in erection dysfunction on diabetes mellitus rat. [J]. Journal of Chongqing Medical University (9):1042-1046(2008)
[1]刘德云,苟欣,蒲晓峰.糖尿病大鼠氧自由基损伤和对超微结构影响致勃起功能障碍的研究[J].重庆医科大学学报,2008(09):1042-1046+1083. DOI：

LIU De-yun, et al. Oxygen free radical damage and it’s effect on ultrastructure result in erection dysfunction on diabetes mellitus rat. [J]. Journal of Chongqing Medical University (9):1042-1046(2008) DOI：

摘要

目的:观察糖尿病（Diabetes mellitus

DM）勃起功能障碍（Erectile dysfunction

ED）大鼠的阴茎海绵体的氧自由基（Oxygen free radical

OFR）

抗氧化水平的变化

并在电镜下观察其形态学变化

进一步探讨糖尿病勃起功能障碍（Diabetes mellitus induced erectile dysfunction

DMED）发病机制。方法:通过链脲佐菌素（Streptozotocin

STZ）诱导的DMED大鼠模型

成模后饲养12周

将动物麻醉后

取其阴茎海绵体进行氧自由基

抗氧化水平等的相关指标测定

并在电镜下观察其超微结构改变。结果:DMED组的氧自由基明显增多

抗氧化水平显著降低

电镜下观察到海绵体平滑肌及血管内皮粗糙、断裂

毛细血管见血栓形成

线粒体肿胀

扩张

成纤维细胞活化

神经纤维髓鞘变性且与对照组等有明显差异。结论:在糖尿病ED中

因氧自由基损伤

抗氧化水平降低

致海绵体组织超微结构改变:平滑肌内皮

血管内皮

神经纤维

线粒体损伤加重并且它们有明显相关性。是DMED的发病机制之一

提示使用氧自由基清除剂

可减轻海绵体组织超微结构改变并改善其阴茎的勃起功能

为DMED的治疗提供又一新的途径。

Abstract

Objective:To observe the change of the oxygen free radical and antioxygen level that existed in cavernous body of penis of diabetus mellitus(DM) rat with erection dysfunction(ED)

and observe the morphology change on the electron microscope to probe into the nosogenesis of DMED. Methods:To make the DMED model on rat by streptozotocin

breed for 12 weeks after it

then to determin the indexes about oxygen free radical and antioxygen level and ultrastructure of cavernous smooth muscle after anesthetize. Results:The level of oxygen free radical increased and antioxygen decreased

the blood capillary thrombogenesised

the chondriosome swelled and distend

the desmocyte activated

the nerve fiber medullary sheath degenerated

all those were observed in the DMED group

and had significant different with control group. Conclusion:The change of ultrastructure occurred in DMED rat induced by the oxygen free radical damage and decrease of antioxygen level

it has associativity with the aggravation of smooth muscle endodermis

the blood vessel endothelium

the nerve fiber and the chondriosome

it’s ONE OF the nosogenesis of DMED.And it suggested to use oxygen free radical scavenger may be relieve the change of ultrastructure and ED

it may be supply anthoer therapy pathway for DMED.

关键词

糖尿病大鼠勃起功能障碍氧自由基超微结构

Keywords

diabetes mellitusratErection dysfunctionOxygen free radicalultrastructure

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Related Institution

Department of Urinary Surgery，the First Affiliated Hospital，Chongqing Medical University

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Department of Endocrinology,The First Affiliated Hospital of Chongqing Medical University

Department of Dermatology,The First Affiliated Hospital of Chongqing Medical University

Department of Endocrinology,Xinqiao Hospital,Third Military Medical University

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