Changes of cerebrospinal fluid albumin index and blood-brain barrier in patients with central nervous system infection

LI Chen-yu; et al

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Changes of cerebrospinal fluid albumin index and blood-brain barrier in patients with central nervous system infection

更新时间：2024-01-17

- Changes of cerebrospinal fluid albumin index and blood-brain barrier in patients with central nervous system infection
- Journal of Chongqing Medical University Issue S1, Pages: 85-86(2008)
- 作者机构：
  
  1. 重庆医科大学附属第一医院神经内科
  2. 重庆医科大学附属第一医院检验科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R529.3;R512.3
- Published：2008，
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[1]李陈渝,李光勤,秦枫.结核性脑膜炎和病毒性脑炎患者的血脑屏障破坏与脑脊液蛋白质指数变化[J].重庆医科大学学报,2008(S1):85-86+104.

LI Chen-yu, et al. Changes of cerebrospinal fluid albumin index and blood-brain barrier in patients with central nervous system infection. [J]. Journal of Chongqing Medical University (S1):85-86(2008)
[1]李陈渝,李光勤,秦枫.结核性脑膜炎和病毒性脑炎患者的血脑屏障破坏与脑脊液蛋白质指数变化[J].重庆医科大学学报,2008(S1):85-86+104. DOI：

LI Chen-yu, et al. Changes of cerebrospinal fluid albumin index and blood-brain barrier in patients with central nervous system infection. [J]. Journal of Chongqing Medical University (S1):85-86(2008) DOI：

摘要

目的:探讨中枢神经系统感染患者血脑屏障（Blood-brain barrier

BBB）与脑脊液（Cerebrospinal-fluid

CSF）白蛋白指数的变化。方法:采用澳甲酚绿法和免疫比浊法检测18例结核性脑膜炎患者急性期、恢复期及23例病毒性脑炎患者急性期的血清和CSF中白蛋白水平

并计算出CSF白蛋白指数

并与正常对照组进行比较。结果:结核性脑膜炎、病毒性脑炎患者急性期CSF白蛋白、CSF白蛋白指数显著高于正常对照组（P<0.001）

且结脑组显著高于病脑组（P<0.001）。结脑组恢复期患者CSF白蛋白、CSF白蛋白指数水平明显低于急性期（P<0.001）。结论:CSF白蛋白和CSF白蛋白指数的水平可作为结核性脑膜炎和病毒性脑炎的早期诊断、鉴别诊断

以及判断BBB损伤程度的参考指标。

Abstract

Objective:To observe the changes of cerebrospinal-fluid albumin index and blood-brain barrier in patients with central nervous system infection. Methods:The levels of albumin in serum and CSF were determined by using immunoturbidimeter method in 18 patients with tuberculous meningitis(TBM) in acute phase and recovery phase

23 patients with viral encephalitis(VE) in acute phase

and 18 normal people. Results:In acute phase

the levels of CSF albumin and CSF albumin index in patients with TBM and VE were obviously higher than those of control group(P<0.001)

and the levels of CSF albumin and CSF albumin index in patients with TBM were obviously higher than those of VE group(P<0.001). In the group of TBM

CSF albumin and CSF albumin index during the recovery stage was lower than acute stage (P<0.001). Conclusion:The levels of CSF albumin and CSF albumin index potentially have an important value in early diagnosis

differential diagnosis and judgement of BBB impairment in TBM and VE.

关键词

中枢神经系统感染结核性脑膜炎病毒性脑炎脑脊液白蛋白指数

Keywords

Central nervous system infectiontuberculous meningitisViral encephalitisCSF albumin index

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